Neuroprotection for Stroke Victims Using Xenon

描述(由申请人提供)：总体的、长期的目标是改善每年数十万中风患者的预后。该方法是(1)证明氙气作为神经保护剂的有效性，并确定最佳治疗方案，以及(2)开发一种可供急救医务人员使用的氙气输送装置，以快速、经济地为中风患者提供神经保护。该项目的具体目标是加强神经保护，极低的环境影响，一个实用和易于使用的系统，以及 总成本。第一阶段将通过(A)动物模型实验证明这种方法的可行性。 (B)在Cream公司进行测试和设计分析，以显示使用氙气进行神经保护的紧凑、轻便和经济的系统的可行性。

DESCRIPTION (provided by applicant): The overall, long-term objective is to improve the outcomes for hundreds of thousands of stroke victims each year. The approach is to (1) demonstrate the effectiveness of xenon as a neuroprotectant and determine the optimal treatment protocol, and (2) develop a xenon delivery apparatus that can be used by emergency medical personnel to quickly and economically provide neuroprotection to stroke victims. The specific aims of the project are enhanced neuroprotection, very low environmental impact, a practical and easy-to-use system, and low overall cost. Phase I will prove the feasibility of this approach with (a) animal model experiments at The University of Massachusetts Medical School (UMass) that will further show the potential effectiveness of xenon as a neuroprotectant and explore optimal treatment protocols, and (b) testing and design analysis at Cream to show the feasibility of a compact, lightweight, and economical system for neuroprotection using xenon.