IC Design and Development for Human Brain Implantations

描述（由申请人提供）：在神经假体领域，需要可植入头皮下并且可从植入人类皮层中的多个电极进行记录的多通道记录系统。这些系统必须具有寿命长，可靠性和高带宽，以记录尖锐的瞬态神经活动。我们在本提案中的目标是建立在我们在2通道系统（最近开发的8通道系统）方面的经验基础上，并将其提升到128通道系统的下一个水平，所有这些都在相同的小尺寸上。 我们的具体目标是：（a）设计用于记录生物信号的高密度集成电路放大器，（B）设计多路复用系统，以及（c）在MOSIS代工厂和台架测试中制造集成电路。 长远目标是（i）将集成电路及多路复用器纳入我们最近完成的混合植入式电子装置，保留使用电源感应模块、校准信号及调频发射器。我们还将开发一个解复用器。(ii)改进功率感应线圈，使其可以在距离受试者头部或包含功率感应接收器线圈的身体部位一定距离处使用。这也将涉及功率放大器的发展，如E型放大器。(iii)将此IC集成到基于LCP的封装或其他基板和互连技术中。(iv)在为人类和动物植入做准备的广泛实验室测试后，将这些器械植入猴子体内。 我们希望这项努力最终能产生一个记录系统，成为人类神经假体植入的标准，从而为减轻人类的痛苦和残疾做出重大贡献。

DESCRIPTION (provided by applicant): In the field of Neural Prostheses, there is a need for multi-channel recording systems that are implantable under the scalp and that can record from multiple electrodes implanted in human cortex. These systems must have longevity, reliability and high bandwith for recording sharp transient neural activity. Our aim in this proposal is to build on our experience with a 2 channel system, a recently developed eight channel system, and take this to the next level of a 128 channel system, all on the same small footprint. Our specific aims are to (a) design high-density integrated circuit amplifiers for recording biological signals, (b) design a multiplexing system, and (c) fabricate the integrated circuit in the MOSIS foundry and bench test. Longer-term aims are to (i) Incorporate the IC and MUX into our recently completed Hybrid Implantable Electronic Device retaining use of the power induction module, calibration signal and FM transmitters. We would also develop a demultiplexer. (ii) Improve the power induction coil so that it can be used at a distance from the subjects' head or body part containing the power induction receiver coil. This will also involve development of a power amplifier such as an E type amplifier. (iii) Incorporate this IC into LCP based packaging or other substrate and inter-connect technology. (iv) Implant these devices into monkeys after extensive bench testing in preparation for human as well as animal implantation. We expect this effort to eventually result in a recording system that will be the standard for human neural prostheses implantations, thus contributing significantly to the alleviation of human suffering and disability.