2004 Barriers of CNS

描述(由申请人提供)：本提案是为支持将于2004年6月27日至7月2日在NH的蒂尔顿举行的第三届“CNS障碍”戈登研究会议而提出的资金申请。还要求为将于2006年和2008年举行的第四次和第五次会议提供支助。戈登研究会议的发起是为了促进来自不同学科的研究人员之间的互动，他们致力于健康和疾病中的血脑屏障(BBB)和血-脑脊液屏障问题。这一领域的研究已经导致开发新的治疗方法，用于治疗中风、头部创伤、神经变性、脑部炎症和脑肿瘤，仅举几例。尽管这些研究领域的一部分代表参加了几次国家和国际研究会议，但该领域的科学家很少有机会聚集在一起，具体集中于与中枢神经系统障碍有关的问题。即将到来的2004年会议将包括与血脑屏障的生理学和病理生理学、血-脑脊液屏障以及向中枢神经系统提供药物和基因疗法有关的问题。2004年会议的一个新方面将是审议神经血管单位以及血脑屏障细胞如何与神经环境中的其他细胞相互作用。尤其值得注意的是，血脑屏障研究已被美国国立卫生研究院确定为发展的关键领域。与此一致，CNS Gordon研究会议障碍的使命是为具有不同背景和经验的科学家提供一个论坛，分享未发表的发现，并共同确定新的战略，以解决与血脑屏障和血液/脑脊液障碍有关的许多剩余悬而未决的问题。为此，来自学术界和制药业的杰出科学家将齐聚一堂，召开一次令人兴奋的“前沿”会议。发言者是根据他们在实地的显赫地位和沟通技巧挑选出来的。他们来自广泛的地理背景。各届会议主席的遴选依据是他们在实地具有相当大的知名度和经验，以及众所周知的良好沟通和辩论能力。此外，正在大力鼓励张贴海报，特别是年轻的博士后和研究生。预计NIH拨款中的相当大一部分将用于资助年轻科学家和教席的出席。还计划在会议期间举办两个公开讲习班/辩论。这次会议允许的最大出席人数是150名科学家。

DESCRIPTION (provided by applicant): This proposal is a request for funds toward support of the 3rd "Barriers of the CNS" Gordon Research Conference to be held June 27th to July 2nd 2004 in Tilton, NH. Funds are also requested for support of the 4th and 5th conferences, to be held in 2006 and 2008. This Gordon Research Conference was initiated as a catalyst for interaction among researchers from a variety of disciplines working on issues of blood-brain-barrier (BBB) and blood-CSF barrier in health and disease. Research in this area is already leading to development of new therapeutic approaches for the treatment of stroke, head trauma, neurodegeneration, brain inflammation and brain tumors, to name a few. Although portions of these areas of investigation are represented at several national and international research meetings, there have been few opportunities for scientists working in the field to come together with a specific concentrated focus on issues related to barriers of the CNS. The upcoming 2004 conference will include issues related to the physiology and pathophysiology of the BBB and blood-CSF barriers as well as the delivery of drug and gene therapies to the CNS. A new aspect of the 2004 meeting will be consideration of the neurovascular unit and how BBB cells interact with other cells in the neural environment. It is especially noteworthy that blood-brain barrier research has been identified by NIH as a critical area for development. Consistent with this, the mission of the Barriers of the CNS Gordon Research Conferences is to provide a forum for scientists with a variety of backgrounds and experience to share unpublished findings and work together to identify new strategies for attacking the many remaining unanswered questions with respect to the BBB and blood/CSF barriers. To this end, eminent scientists from both academia and the pharmaceutical industry are being brought together for an exciting "leading edge" meeting. Speakers have been selected on the basis of their eminence in the field and their communication skills. They are drawn from a wide geographical background. Chairs of the sessions have been selected on the basis of their considerable eminence and experience in the field and a known ability to communicate and debate well. In addition the presentation of posters is being vigorously encouraged especially by young postdoctoral and research students. It is expected that a considerable proportion of any NIH grant will be used to fund the attendance of young scientists and chairs. Two open workshops/debates to occur during the meeting are also planned. The maximum permitted attendance at this meeting is 150 scientists.