4Th Annual Mutant Mouse Regional Resource Center Meeting

描述(由申请人提供)： 为了应对科学界日益增长的获得突变小鼠进行生物医学研究的需求，国家研究资源中心(NCRR)/NIH的比较医学计划(CMP)建立了四个突变小鼠区域资源中心(MMRRC)和一个连接这四个中心的电子网络(信息学协调中心-ICC)。MMRRC的目标是开发能够饲养、超低温保存、再衍生、表型鉴定、维护小鼠资源数据库和提供高水平遗传和微生物质量控制的突变小鼠分发设施。U42资助机制还支持每个MMRRC的应用研究，旨在改善资源并加强NIH生物医学研究企业。MMRRC网络于1999年建立，这一复杂方案的治理和后勤得到了优化，MICE正在提交给MMRRC，MICE现在可以分发。 该提案请求支持将于2004年3月举行的MMRRC第四次年度会议。会议将为MMRRC计划主任、ICC计划主任、外部指导委员会、MMRRC小组委员会主席和其他MMRRC关键人员提供一个论坛，与NCRR计划工作人员会面，讨论与推进MMRRC和NCRR计划目标有关的问题。此外，会议将为NIH项目的其他工作人员提供一个论坛，以提供对MMRRC概念的意见，并与科学小鼠社区的主要代表协调努力，代表NCI(癌症小鼠模型)、化学诱变小鼠、基因捕获/胚胎干细胞小鼠档案、Cre-loxP小鼠等。今年的会议将持续11天半，将包括一个与实验室小鼠相关的科学计划。因此，会议的一部分将向普通科学界开放。拟议的会议将确保MMRRC计划继续取得成功，允许为改进该计划提供投入，并为科学和专业人士提供一个教育论坛，与MMRRC和NCRR的计划目标保持一致。

DESCRIPTION (provided by applicant): In response to the growing demand of the scientific community to have access to mutant mice for biomedical research, the Comparative Medicine Program (CMP) of the National Center for Research Resources (NCRR)/NIH has established four Mutant Mouse Regional Resource Centers (MMRRCs) and an electronic network that links the four centers (the Informatics Coordinating Center - ICC). The goals of the MMRRCs are to develop mutant mouse distribution facilities capable of husbandry, cryopreservation, rederivation, phenotypic characterization, maintenance of a mouse resource database and a provision of high-level genetic and microbial quality control. The U42 funding mechanism also supports applied research at each of the MMRRCs that is intended to improve the resource and enhance the NIH biomedical research enterprise. The MMRRC network was established in 1999, the governance and logistics of this complex program have been optimized, mice are being submitted to the MMRRCs and mice are now available for distribution. This proposal requests support for the fourth Annual MMRRC Meeting to be held in March of 2004. The meeting will provide a forum for the MMRRC Program Directors, the ICC Program Director, an External Steering Committee, MMRRC Subcommittee Chairpersons, and other key MMRRC personnel to meet with NCRR program staff to discuss issues relating to advancing the MMRRC and NCRR program goals. In addition, the meeting will provide a forum for other NIH program staff to provide input into the MMRRC concept, and to coordinate efforts with the key representatives of the scientific mouse community, representing NCI (mouse models of cancer), chemically mutagenized mice, gene trapping/embryonic stem cell mouse archives, CRE-LoxP mice, etc. This year's meeting will be 11/2 days and will include a scientific program with relevance to the laboratory mouse. Thus, a portion of the meeting will be open to the general scientific community. The proposed meeting will assure the continued success of the MMRRC program, allow input into improving the program and to provide an educational forum for the scientific and professional community, in keeping with the program aims of the MMRRCs and the NCRR.