2004 Mutagenesis Gordon Conference

描述(由申请者提供)：申请资助科学家参加第14届戈登突变研究会议的旅费和/或会议费，该会议将于2004年9月12-17日在英国牛津女王学院举行。会议将侧重于突变和DNA修复的基本机制，并将强调突变在进化过程和人类疾病方面的生物学影响。选定的发言者将是诱变领域的专家，会议将成为所有与会科学家通过每届会议的公开讨论和海报演示进行广泛互动的论坛。会议通常超额认购，出席人数限制为135人。将作出具体努力，并特别考虑鼓励少数群体、妇女、研究生和残疾人参加。会议将在第一个晚上开幕，发表两个主题演讲，从历史的角度审视诱变领域。随后将举行八个上午/晚上的正式会议，重点讨论：(I)诱变系统，(Ii)超可变序列，(Iii)突变机制，(Iv)突变避免系统，(V)人类遗传和传染病中的突变，(Vi)进化和基因表型关系中的突变率，(Vii)生态学、诱变和进化模型，()人类种群的遗传多样性和人类诱变模型。会议最后将举行一次主旨演讲，总结会议上提出的成果和想法。突变领域对人类健康至关重要，因为突变会引发和促进多种人类疾病的进展，特别是癌症和神经退行性疾病。此外，诱变过程在控制宿主-寄生虫相互作用方面也很重要，氧化损伤的积累与衰老有关。

DESCRIPTION (provided by applicant): Funds are requested to support travel and/or conference fees for scientists attending the 14th bi-annual Gordon Research Conference on Mutagenesis to be held at The Queen's College, Oxford, UK, September 12-17, 2004. The Conference will focus on the basic mechanisms of mutagenesis and DNA repair, and also will emphasize the biological implications of mutations in terms of evolutionary processes and human disease. Selected speakers will be experts in the field of mutagenesis, and the meeting will serve as a forum for extensive interactions among all attending scientists through open discussions within each session as well as poster presentations. The Conference is usually heavily oversubscribed, with attendance being limited to 135 participants. Specific efforts will be made and special consideration given to encouraging the attendance of minority groups, women, graduate students, and persons with disabilities. The conference will open on the first evening with two keynote addresses that will provide a historical perspective on the field of mutagenesis. This will be followed by eight formal morning/evening sessions focusing on: (i) mutagenic systems, (ii) hypermutable sequences, (iii) mechanisms of mutation, (iv) mutation avoidance systems, (v) mutation in human hereditary and infectious diseases, (vi) mutation rates in evolution and genotypephenotype relationships, (vii) ecology, mutagenesis and the modeling of evolution and (viii) genetic diversity of the human population and models for human mutagenesis. The Conference will close with a keynote lecture that will provide a synthesis of the results and ideas presented at the meeting. The field of mutagenesis is critical to human health because mutations initiate and facilitate the progression of a multitude of human diseases, especially cancer and neurodegenerative diseases. In addition, mutagenic processes are important in controlling host-parasite interactions, and the accumulation of oxidative damage has been implicated in aging.