Mathematical Models in Signaling Systems

描述（由申请人提供）：要求支持部分承担题为“信号系统中的数学模型”会议的费用。本次会议的目标是将生物学家、物理学家、数学家、计算科学家和生物信息学家聚集在一起，评估导致细胞反应的信号转导网络的定量和计算建模的最新技术，确定一套方法和想法，追踪未来的方向，并为跨学科科学的学生和年轻科学家提供一个参考论坛。演讲者和参与者被选中提供一系列建模方法，包括随机和确定性建模，以及对细胞信号网络的见解。前两节课的重点将放在建模过程上，该过程既考虑了信号通路每个组成部分在细胞中的空间定位，也考虑了生理状态的时间变化。在最后两节课中，将讨论理解细胞信号网络的实验和理论方法。

DESCRIPTION (provided by applicant): Support is requested to partially underwrite the costs of a conference entitled "Mathematical Models in Signaling Systems." The goal of the proposed meeting is to bring together biologists, physicists, mathematicians, computational scientists and bioinformaticians to assess the state of the art in quantitative and computational modeling of signal transduction networks leading to cellular responses, identify a set of methods and ideas, trace future directions and provide a reference forum for students and young scientists versed in interdisciplinary sciences. The speakers and participants have been chosen to provide a spectrum of modeling approaches, including stochastic and deterministic modeling, as well as insights obtained about cellular signaling networks. The emphasis in the first two sessions will be on modeling processes that take into account both the spatial localization in the cell of each component of the signaling pathway, as well as the temporal changes in physiological state. In the last two sessions, experimental and theoretical approaches to understanding cellular signaling networks will be discussed. Finally, a goal of this meeting is to attract young investigators by the inclusion of travel awards, including those considered underrepresented in science fields, such as women and minorities.