LENT V CONFERENCE

描述(由申请人提供)：有令人信服的理由组织RTOG放射生物生理学和生物病理学翻译研究研讨会，纳入新的分子生物学和遗传学概念，寻找可量化的替代生物标记物，用于对正常组织的不良影响进行分级。此外，创新的治疗干预措施已经并将被设计来基于分子机制来减轻不良反应。其他目标是开发一个报告不良反应的标准统计模型和一个统一的方法来得出总结或全球毒性评分。在发生辐射生物恐怖事件时，可以利用替代生物标记物的目标来确定暴露在辐射中的个人。参与的教员将被邀请到临床科学家和长期对正常组织的后期效应感兴趣的研究人员(大斋期)。将向所有主要的国家肿瘤学合作组织和EORTC发出公开邀请，以促进验证方案并激发人们对建立有意义的治疗比率的兴趣。会议将在罗切斯特大学癌症中心、纪念艺术馆和AAB基础科学礼堂举行。一些重要议题将在一系列以机构为重点的小型讲习班上讨论。选定的会议日期为2004年5月19日、20日、21日、22日。

DESCRIPTION (provided by applicant): There are compelling reasons to organize an RTOG translational research workshop in radiation biophysiology and biopathology incorporating new molecular biologic and genetic concepts in search of quantifiable surrogate biomarkers for grading adverse effects in normal tissues. In addition, innovative therapeutic interventions have been and will be designed to ameliorate adverse effects based on molecular mechanisms. Additional goals are to develop a standard statistical model for reporting adverse effects and a unified approach to arriving at a summary or global toxicity score. The goal of surrogate biomarkers can be utilized in the event of radiation bioterror to determine individuals that have been exposed to radiation. The participating faculty will be invited clinical scientists and researchers with a long-standing interest in Late Effects of Normal Tissues (LENT). An open invitation will be made to all major National Oncology Cooperative Groups and the EORTC to foster validation protocols and stimulate interest in establishing meaningful therapeutic ratios. The meeting will be held at the University of Rochester Cancer Center, The Memorial Art Gallery, and the AAB Basic Science Auditoriums. A number of vital topics will be addressed in a series of small focused workshops which will be organ oriented. The dates selected for the Conference are May 19, 20, 21,22 2004.