Signaling in Vertebrate Organogenesis

描述（由申请人提供）：人类健康中最具挑战性的问题之一是了解是什么控制着身体各器官的发育，以及发育如何出错导致先天性畸形。对器官形成的基本机制的了解是目前许多关于如何设计治疗许多疾病的想法的基础，包括糖尿病，心脏病和帕金森病。从过去十年的研究中得到的一个主要教训是，启动和维持身体不同器官发育的信号在很大程度上被保存了下来。因此，通过了解控制其他器官发育的机制，可以了解一个器官的发育。然而，科学家们并没有太多的机会从这样一个广泛的角度来讨论器官发生。该提案要求为Gall Martin和Clifford Tabin共同组织的关于“脊椎动物器官发生中的信号传递”的Keystone研讨会提供部分支持。本次会议的目标是为在各种系统中工作的科学家提供一个论坛，以交流有关脊椎动物器官发生的分子机制的想法，并考虑异常发育如何导致疾病。研讨会将汇集约150名杰出的高级和初级科学家，讨论器官发育研究的最新进展，包括肺，乳腺，肾，胰腺，肝，心脏，皮肤，骨骼，脊髓。会议形式将包括简短的会谈（约20分钟），然后进行讨论（约10分钟）。通过最大限度地发挥正式讨论和非正式互动的作用，研讨会应有助于确定该领域的现状和未来，并帮助年轻的研究人员，特别是研究生和博士后研究员，拓宽他们的视野，引导他们的研究新的方向。

DESCRIPTION (provided by applicant): One of the most challenging problems in human health is to understand what controls the development of the various organs of the body and how development can go awry to cause congenital malformations. Knowledge of the fundamental mechanisms of organ formation underlies many of the current ideas for how to devise cures for numerous diseases, including diabetes, heart disease, and Parkinson's disease. One of the major lessons from the last decade of research is that the signals that initiate and sustain the development of the different organs of the body have been largely conserved. Thus, much can be learned about the development of one organ by knowing about the mechanisms that control the development of others. However, there are not many opportunities for scientists to meet and discuss organogenesis from such a broad perspective. This proposal requests funds for partial support of a Keystone Symposium on "Signaling in Vertebrate Organogenesis" co-organized by Gall Martin and Clifford Tabin. The goal of this conference is to provide a forum for scientists working in a variety of systems to exchange ideas about the molecular mechanism of vertebrate organogenesis and to consider how abnormal development can lead to disease. The Symposium will bring together ~150 outstanding senior and junior scientists for discussions of the recent advances in studies of organ development, including lung, mammary gland, kidney, pancreas, liver, heart, skin, skeleton, spinal cord. The conference format will consist of short talks (~20 minutes) followed by discussion (~10 minutes). By maximizing both formal discussion and informal interactions the Symposium should help to define both the present state and future of the field, and help young investigators, particularly graduate students and postdoctoral fellows, to broaden their perspectives and guide their research in new directions.