Catalytic and biocatalytic C-X bond formation

该项目将专注于开发使用生物启发氢键供体催化剂的C-X键活化和C-X键形成的新催化方法。该项目最初将专注于C-F键的激活和C-B键的安装，但可能会扩展到其他系统。该项目将涉及模型系统的合成，以了解所需的键激活/形成。这将导致一种方法，包括优化阶段，催化剂建模和范围评估。在整个过程中，物理-有机化学技术将用于了解机制并告知正在开发的过程。

This project will focus on the development of new catalytic approaches for C-X bond activation and C-X bond formation using bioinspired hydrogen bond donor catalysts. The project will initially focus on the activation of C-F bonds and installation of C-B bonds but will likely expand to other systems. The project will involve synthesis of model systems to understand the desired bond activation/formation. This will lead to a methodology encompassing optimisation stages, catalyst modelling, and assessment of scope. Throughout, physical-organic chemistry techniques will be used to understand mechanism and inform on the process under development.