Multidisciplinary Clinical Research Career Develop(RMI)

描述(由申请人提供)：北卡罗来纳大学寻求建立一个多学科临床研究职业发展计划(MCRCDP)，旨在培训CR学者。MCRCDP的目标是招募一批来自至少四个学科的研究员和初级敏锐度成员，然后为他们在多学科临床研究中的职业生涯做好准备。我们的课程包括教学部分(正式课程、研讨会、小组活动、工作坊)，使CR学者了解和欣赏：a)不同的临床研究学科；b)设计严格临床研究所必需的方法学和分析概念；c)与负责任的研究行为相关的基本原则和概念。该课程还包括实践经验，包括：有指导的研究实习(1年级)；有指导的研究项目(2年级)；以及独立研究项目(3-5年级)，以获得未来的研究资金。正如设想的那样，这一MCRCDP将涵盖临床研究的全部范围。 北卡罗来纳大学MCRCDP的优势包括：a)在K30和RWJ临床学者计划的基础上为临床研究人员提供全面的课程；b)机构承诺和行政结构，促进跨各种学科和单位(例如，学校、科室、NIH资助的中心)的合作；c)具有大型、资金充足的多学科临床研究基础的导师；d)强大的公共和私人伙伴关系，将增强CR学者的经验；e)招聘计划，以吸引来自卫生事务校园所有五所学校的优秀国家候选人和当地申请者；F)指导战略，以确保每个学者在实现研究独立方面取得进展；和g)来自共享研究设施的生物统计和数据管理支持。北卡罗来纳州大学是主办这一MCRCDP的独特之地。首先，它沿着传统的从病床到床边到实践的连续体系进行临床研究已经有很长的历史了。其次，它有许多多学科的研究团队，具有协同作用，使北卡罗来纳大学的调查人员能够从广泛不同的角度处理复杂的问题。最后，还有初级调查人员培训方面的记录。因此，对MCRCDP的资助，再加上对专用空间和资源的重大机构承诺，将使北卡罗来纳大学能够培训进行与路线图目标一致的研究的科学家：“加快在疾病预防、检测和诊断方面发现新知识的速度，并将这些发现转化为将改善国家健康的应用。”

DESCRIPTION (provided by applicant): UNC seeks to establish a Multidisciplinary Clinical Research Career Development Program (MCRCDP) designed to train CR scholars. The objectives of the MCRCDP are to recruit a cohort of fellows and junior acuity members drawn from at least four disciplines and then prepare them for careers in multidisciplinary clinical research. Our curriculum includes a didactic component (formal courses, seminars, small group activities, workshops) that will provide CR scholars with an understanding of and appreciation for: a) diverse clinical research disciplines; b) methodological and analytic concepts necessary to design rigorous clinical research; and c) underlying principles and concepts of bioethics related to the responsible conduct of research. The curriculum also has a practicum experience that includes: a mentored research internship (Year 1); a mentored research project (Year 2); and an independent research project (Years 3-5) that leads to future research funding. As envisioned, this MCRCDP will embrace the full spectrum of clinical research. Strengths of the UNC MCRCDP include: a) a comprehensive curriculum for clinical researchers that build upon both the K30 and RWJ Clinical Scholars Programs; b) an institutional commitment and administrative structure that fosters collaboration across a wide variety of disciplines and units (e.g., Schools, Departments, NIH-funded Centers); c) mentors with large, well-funded bases of multidisciplinary clinical research; d) strong public and private partnerships that will enhance the experience for CR scholars; e) a recruitment plan to attract outstanding national candidates as well as local applicants from all five Schools on the Health Affairs Campus; f) mentoring strategies to ensure that each scholar makes progress towards research independence; and g) biostatistical and data management support from a shared research facility. UNC is uniquely positioned to host this MCRCDP. First, it has a long history of conducting clinical research along the traditional bench-to-bedside-to-practice continuum. Second, it has many multidisciplinary research teams with synergies that enable UNC investigators to approach complex problems from widely differing perspectives. Finally, there is the track record in the training of junior investigators. Thus funding of this MCRCDP, combined with a substantial institutional commitment for dedicated space and resources, will enable UNC to train scientists who conduct research consistent with the Roadmap goal: "to accelerate both the pace of discovery of new knowledge in the prevention, detection, and diagnosis of disease and the translation of these discoveries into applications that will improve the health of the nation."