Scholar Development Clinical Research (RMI)

描述（由申请人提供）：从实验室获得的关于基本疾病机制的知识的急剧增长，在走向床边、诊所或普通人群方面进展缓慢。这些延误部分是由于缺乏足够的训练有素的临床研究人员将科学发现转化为人类。认识到这一不足，明尼苏达大学及其学术健康中心（AHC）在2003年制定了一项战略计划，优先考虑从本科生到高级教员的所有大学级别的临床研究（CR）。拟议的K12项目很好地符合这些计划，并将增加明尼苏达州CR的大量投资。

DESCRIPTION (provided by applicant): Dramatic increases in the knowledge of basic disease mechanisms from the laboratory are slow to find their way to the bedside, clinic, or general population. These delays are due, in part, to a lack of enough well-trained clinical researchers to translate scientific discoveries in human populations. Recognizing this deficit, the University of Minnesota and its Academic Health Center (AHC) developed a strategic plan in 2003 prioritizing clinical research (CR) at all University levels from undergraduates to the senior faculty. The proposed K12 program fits well into those plans and will enhance the substantial Minnesota CR investment. This K12 proposal embraces the spectrum of CR from observational epidemiology to clinical trials to outcomes research. Recognizing the multidisciplinary nature of CR, the applicant includes the Schools of Dentistry, Medicine, Nursing, Pharmacy, and Public Health in CR scholar identification, training, and development. These disciplines have a history of working together to provide leadership for CR. Beginning with clinical specialty fellows, postdoctoral students, and junior faculty, CR scholars will be selected to participate in current and new coursework from an ongoing K30 program. Advised by three-person multidisciplinary mentor teams, including a biostatistician, the scholars will access substantial resources and infrastructure in the AHC including: 1) Skilled, experienced, and enthusiastic senior mentors; 2) Biostatisticians with an international reputation for CR; 3) A General Clinical Research Center (GCRC) with a 25-year record of productivity; 4) A Pharmaceutical Center; 5) Department of Veterans Affairs and Hennepin County hospitals with diverse populations; 6) A minority recruitment program; 7) A substantial portfolio of federal and industry funded CR projects, and; 8) A proposed Shared Clinical Research Support Group. There is a history of collaboration among AHC schools in multidisciplinary CR using a team approach. This application expands on a successful CR enterprise in an institution with a ten-year strategic investment plan. The goal is to improve health and cure diseases through CR. This application merges many University of Minnesota strengths in a systematic, focused career development training program for NIH CR scholars.