Pediatric AIDS Clinical Trials Unit

描述(由申请人提供)：芝加哥儿科艾滋病诊所 试验单位(C-PACTU)计划参加多中心艾滋病临床 由协调和业务中心(CORC)提议的试验。我们的目标是 参与以假设为基础和以发病机制为导向的方案 旨在1)确定病毒学和免疫学机制的试验 并评估抗逆转录病毒药物的潜力和 免疫调节剂(包括疫苗)以减少这种传播。2) 迅速评估有前景的抗逆转录病毒新组合的效果 病毒载量、免疫标志物和/或临床结果；3)增加我们的 对儿童和青少年HIV免疫发病机制的认识 基于免疫和/或基因治疗的作用；4)预防或管理机会主义 感染，并调查其对艾滋病毒感染进展的影响； 5)促进艾滋病毒感染者的登记、治疗和依从性 6)提高生活质量和长期结果。我们有 对第一阶段/第二阶段研究特别感兴趣，并计划继续参与 在这些(更难的)协议中。此外，我们计划增加 年在我们单位接受护理的艾滋病毒感染妇女的参与 ACTG研究。拟议的C-PACTU的四个单位位于不同的 芝加哥市的部分地区。C-PACTG的大范围集水区和 它与许多社区机构建立的联系将使我们能够 为了有效地接触到许多已知的儿童、青少年和妇女 受芝加哥及周边地区艾滋病疫情影响。该单位是 还从事国际科学交流和研究的现场 在南非开普敦。

DESCRIPTION (provided by applicant): The Chicago Pediatric AIDS Clinical Trials Unit (C-PACTU) plans to participate in the multi-center AIDS clinical trials proposed by the Coordinating and Operations Center (CORC). Our goal is to participate in protocols that are hypothesis-based and pathogenesis-oriented trials designed to 1) define the virologic and immunologic mechanisms of perinatal transmission and evaluate the potential of antiretrovirals and immunomodulators (including vaccines) to reduce such transmission. 2) expeditiously evaluate the effect of promising new antiretroviral combinations on viral load, immunologic markers and/or clinical outcome; 3) increase our understanding of HIV immunopathogenesis in children and adolescents and the role of immune-based and/or gene therapy; 4) prevent or manage opportunistic infections and investigate their effect on the progression of HIV infection; 5) facilitate enrollment, treatment, and compliance of HIV-infected adolescents; and 6) increase quality of life and long-term outcomes. We have special interest in phase I/II studies and plan to continue our participation in these (more difficult) protocols. In addition, we plan to increase participation of HIV-infected women who are being cared for at our unit in ACTG studies. The proposed four units of the C-PACTU are located in different parts of the city of Chicago. The wide-range catchment area of the C-PACTG and the linkages it has developed with many community-based agencies will allow us to reach effectively many of the children, adolescents and women known to be affected by the HIV epidemic in Chicago and the surrounding area. The unit is also engaged in international scientific exchange and research with a site in Capetown, South Africa.