INFLAME: Inflammation and Exercise

描述(由申请人提供)：C-反应蛋白(CRP)是全身炎症的标志，据报道，它是女性和男性心血管疾病的独立预测因子。我们最近发表的横断面分析数据显示，C反应蛋白与心肺功能呈负相关，而且这种关系与体重指数无关。定期锻炼可能会影响CRP，这为降低升高的CRP提供了一种干预措施。虽然有一些研究集中在相关主题上，但据我们所知，还没有发表过关于单独运动训练对CRP影响的随机临床试验的报告。这项名为炎症与运动(IFAME)的拟议研究的目标是确定运动训练对最初久坐不动的女性和男性(18至75岁)C反应蛋白浓度升高(等于或大于2.0 mg/L)的影响。我们将170名受试者随机分配到不锻炼对照组或锻炼组。锻炼的个人将参加为期4个月的每周3到4次训练，总能量消耗为16千卡。Kg(-1)。一周(-1)，这是目前公共卫生推荐的体力活动上限的运动量。目标运动强度将是基线最大摄氧量的50%-70%。主要的预后指标是血浆C反应蛋白浓度。次要结果是变量的变化，这些变量是经常锻炼可能降低CRP的潜在机制。这些因素包括内脏肥胖，细胞因子IL-6和TNF-α，以及心率变异性作为自主神经平衡的衡量标准。这项拟议研究的另一个优势是，尽管主要结果是C反应蛋白，但这项研究也将对检验运动对内脏肥胖、细胞因子和心率变异性变量的影响的有限文献做出重大贡献。

DESCRIPTION (provided by applicant): C-reactive protein (CRP), a marker of systemic inflammation, has been reported to be an independent predictor of cardiovascular disease in both women and men. We recently published data from cross-sectional analyses showing that CRP is inversely related to cardiorespiratory fitness, and that this association is independent of body mass index. The possibility that regular exercise may affect CRP presents an intervention to evaluate for reducing elevated CRP. Though there are a number of studies focusing on related topics, to our knowledge there are no published reports from randomized clinical trials on the effect of exercise training alone on CRP. The goal of the proposed study, Inflammation and Exercise (INFLAME), is to determine the effect of exercise training on elevated (equal to or greer than 2.0 mg/L) CRP concentrations in initially sedentary women and men (18 to 75 years old). We will randomly assign 170 individuals equally to a no exercise control group or to an exercise group. Exercising individuals will participate in 3 or 4 training sessions each week for 4 months progressing to a total energy expenditure of 16 kcal . kg(-1) . week(-1), which is an exercise dose at the upper end of current public health recommendations for physical activity. The target exercise intensity will be 50-70% of baseline VO2 max. The primary outcome measure is plasma CRP concentration. Secondary outcomes are changes in variables that are potential mechanisms whereby regular exercise might reduce CRP. These include visceral adiposity, the cytokines IL-6 and TNF-alpha, and heart rate variability as a measure of autonomic balance. An additional strength of this proposed study is that although the primary outcome is CRP, this study would also contribute significantly to the limited body of literature examining the effect of exercise on the variables of visceral adiposity, cytokines, and heart rate variability.