MULTIDISCIPLINARY TRAINING IN EXPERIMENTAL HEMATOLOGY

描述（申请人摘要）本申请申请建立血液病的多学科研究培训计划。血液病仍然是美国发病率和死亡率的主要来源。梅奥诊所有培养学术血液学家的悠久传统。最近的分析表明，大约一半的梅奥诊所血液学/肿瘤学临床奖学金项目的应届毕业生在获得奖学金后从事实验室研究工作。为了更好地装备这些学术医生，以及对血液疾病感兴趣的合适的博士科学家，以便后续追求假设驱动的实验室研究，我们设计了血液学研究培训计划。培训师资队伍由32名外部资助的研究人员组成，他们的实验室研究项目包括：1)髓系和淋巴系恶性肿瘤，2)细胞因子，3)凝血和微循环，4)分子治疗，5)实验免疫学，6)临床和遗传流行病学。每个受训者将被期望在其中一个培训学院的实验室完成至少两年的假设驱动研究。通过参加生物化学和分子生物学研讨会、血液学核心部的教学讲座以及GCRC的“研究的实践方面”课程，学生将获得实践研究经验。此外，我们鼓励学员根据需要选修生物化学、免疫学、分子生物学、生理学、分子药理学或肿瘤生物学课程，以扩展他们在研究项目相关领域的知识基础。我们最初计划每年招收1-2名学员，并以每年3名学员为稳定项目。血液学研究培训项目将由Scott Kaufmann， m.d., Ph.D.和Robert A. Kyle, m.d.共同指导，他们都是外部资助的研究人员，主要研究血液学疾病。该项目将由一个四人委员会管理，其中包括博士。考夫曼和凯尔。我们将寻找具有医学博士，博士或医学博士/博士学位的合格候选人。背景。已经建立了积极征聘合格的少数民族和妇女候选人的机制。该项目是血液学现有培训机会的自然产物，但将为血液学疾病的实验室研究提供更好的准备。（摘要结束）

DESCRIPTION (Applicant's Abstract) This application requests support to establish a new multidisciplinary research training program in hematological diseases. Hematological diseases remain a major source of morbidity and mortality within the United States. The Mayo Clinic has a long tradition of training academic hematologists. Recent analysis indicates that approximately half of the recent graduates of the Mayo Clinic hematology/oncology clinical fellowship program have laboratory research commitments following fellowship. To better equip these academic physicians, as well as suitable Ph.D. scientists interested in hematological diseases, for subsequent pursuit of hypothesis-driven laboratory investigation, we have designed a Hematology Research Training Program. The training faculty consist of 32 extramurally funded investigators with laboratory research programs in 1) myeloid and lymphoid malignancies, 2) cytokines, 3) coagulation and microcirculation, 4) molecular therapeutics, 5) experimental immunology, and 6) clinical and genetic epidemiology. Each trainee will be expected to complete at least two years of hypothesis-driven research in the laboratory of one of these training faculty. This hands-on research experience will be supplemented by required attendance at Biochemistry & Molecular Biology seminars, Division of Hematology Core didactic lectures, and a GCRC course on "Practical Aspects of Research." In addition, trainees will be encouraged to take additional biochemistry, immunology, molecular biology, physiology molecular pharmacology or tumor biology courses as needed to extend their knowledge bases in areas related to their research projects. We initially propose to recruit 1-2 trainees per year, with a steady state program of three trainees. This Hematology Research Training Program will be co-Directed by Scott Kaufmann, M.D., Ph.D., and Robert A. Kyle, M.D., both of whom are extramurally funded investigators with programs focused on hematological diseases. The program will be administered by a four member committee that includes Drs. Kaufmann and Kyle. We will seek qualified candidates with M.D., Ph.D., or M.D./Ph.D. backgrounds. Mechanisms are in place for aggressive recruitment of qualified minority and women candidates. This program is a natural outgrowth of existing training opportunities in hematology, but will provide better preparation for laboratory research in hematological diseases. (End of Abstract)