PROGRAM OF RESEARCH TRAINING IN REPRODUCTIVE BIOLOGY

超出所提供的空间。 这个建立和不断发展的跨学科计划的目的是培养博士后和博士后研究员在分子生物学，内分泌学，分子遗传学和生殖的综合生理学。有17名博士后和51名博士前学员，他们具有一个或多个生物学科的背景经验，如内分泌学、生殖生物学、神经生物学和分子生物学。15名教师，谁arenappointed在四个学科相关的部门-动物科学，生物化学，分子和综合生理学，兽医生物科学（一些教师是交叉任命细胞和结构生物学）-提供了很大的广度和深度的研究培训机会。目前关于各类生殖激素的项目涵盖了男性和女性生殖生物学的许多方面。在分子、细胞、器官和整个动物水平上对小型和大型动物进行研究。正在进行的研究项目直接关系到与国家保健有关的主要目标，如调节男女生育力，阻止激素依赖性乳腺癌和前列腺癌的生长，提供绝经后保护，防止骨脱矿，了解子宫内膜异位症和子宫肌瘤的原因并确保治疗，防止分娩时间过长和难产，并描述环境中破坏生殖系统的物质。博士后研究生主要从事独立的原创性研究，一般在3-4年内完成培训。博士预科生在开始独立研究之前，要学习内分泌学和生殖生理学以及相关主题，如生物化学，分子生物学，免疫学和统计学。完成博士前培训通常需要4-5年的时间，其中大部分时间用于进行独立研究。受训人员和工作人员参加每周一次的研究会议，讨论研究建议和进展。他们还通过每周参加一次高级内分泌学研讨会，深入了解他们所从事的研究领域。在这次研讨会上，学生和工作人员提出了批判性的评论和当前的进展，在一个特定的研究领域在整个15周的时间。每年两次的教师和学员参加教学在负责任的研究行为。受训人员出席国家科学会议并提交论文。来自其他机构的科学家访问我们的实验室，与学生和教师进行咨询，并举办研讨会。教师实验室能够支持多样化的培训计划，因为它们是大型，现代化和设备齐全。他们配备了研究，涉及各种分子生物学技术以及蛋白质分离和表征，组织学，放射自显影，组织培养和激素测定程序。该大学还提供以下支持生物医学研究的现代研究设施：动物护理单位（小型和大型动物的住房和手术设施），免疫资源中心，蛋白质科学设施（序列测定，肽合成和质谱），流式细胞术设施，W。M.凯克比较和功能基因组学中心（微阵列技术，DNA测序，寡核苷酸合成，功能基因组学，高通量测序和生物信息学），贝克曼成像技术集团和显微成像中心。为三名博士后和五名博士前学员寻求财政支助。性能现场=

EXCEED THE SPACE PROVIDED. The purpose of this established and growing interdisciplinary program is to train postdoctoral and predoctoral fellows in the molecular biology, endocrinology, molecular genetics, and integrative physiology of reproduction. There are 17 postdoctoral and 51 predoctoral trainees, and they have background experience in one or more biological disciplines, such as endocrinology, reproductive biology, neurobiology and molecular biology. Fifteen faculty members, who areappointed in four discipline-related departments - Animal Sciences, Biochemistry, Molecular andIntegrative Physiology, and Veterinary Biosciences (some faculty are cross-appointed in Cell and Structural Biology) - provide great breadth and depth in research training opportunities. Current projects on all classes of reproductive hormones cover many aspects of both male and female reproductive biology. Studies are conducted on both small and large animals at the molecular, cellular, organ, and whole animal levels. Ongoing research projects relate directly to major national health-related objectives, such as regulating male and female fertility, arresting the growth of hormone- dependent mammary and prostate cancer, providing postmenopausal protection from bone demineralization, understanding the causes of and securing treatment for endometriosis and uterine fibroids, preventing prolonged and difficult delivery, and characterizing substances within the environment that disrupt the reproductive system. Postdoctoral trainees are involved principally in independent original research, and they generally complete their training in 3-4 years. Predoctoral trainees take courses in endocrinology and physiology of reproduction as well as related topics, such as biochemistry, molecular biology, immunology, and statistics before beginning independent research. The majority of the 4-5 years that are generally required to complete predoctoral training is spent conducting independent research. Trainees and staff participate in a weekly research conference to discuss research proposals and progress. They also gain a solid understanding of research areas beyond that in which they are engaged by participating weekly in an advanced endocrinology seminar. In this seminar, students and staff present critical reviews and current advances in a specific research area throughout a 15-week period. Twice each year faculty and trainees participate in instruction in the responsible conduct of research. Trainees attend and present papers at national scientific meetings. Scientists from other institutions visit our laboratories to consult with students and faculty and to present seminars. Faculty laboratories are capable of supporting a diverse training program because they are large, modern and well equipped. They are equipped for research that involves a variety of molecular biology techniques as well as procedures in protein isolation and characterization, histology, autoradiography, tissue culture, and hormone assays. The University also provides the following modern research facilities that support biomedical research: Animal Care Units (housing and surgery facilities for small and large animals), Immunological Resource Center, Protein Sciences Facility (sequence determination, peptide synthesis and mass spectrometry), Flow Cytometry Facility, W. M. Keck Center for Comparative and Functional Genomics (microarray technologies, DNA sequencing, oligonucleotide synthesis, functional genomics, high throughput sequencing, and bioinformatics), Beckman Imaging Technology Group and the Center for Microscopic Imaging. Financial support is sought for three postdoctoral and five predoctoral trainees. PERFORMANCE SITE ========================================Section End===========================================