Depression in Children /Adolescents with Type 1 Diabetes

描述（由申请人提供）： 这个K23指导以患者为导向的研究职业发展奖的候选人是一个研究员推进到初级教师职位。候选人的长期目标是在儿科糖尿病领域开展学术研究，以开发和加强有效的，药物支持的方法，改善儿童，青少年及其家庭的健康状况和生活质量。通过该奖项实现的具体短期职业目标包括：1）发展研究方法方面的专业知识，以更好地了解青年及其家庭的情绪功能对1型糖尿病相关管理和健康结果的影响，2）关注1型糖尿病青年的抑郁症，并确定1型糖尿病青年抑郁症的预测因素，3）描述干预和/或预防的可修改因素，以准备R 01申请，重点是干预和预防1型糖尿病儿童和青少年的抑郁症。为了实现这些目标，候选人提出了一个为期五年的培训计划。候选人的主要导师在儿科学和流行病学方面有很强的背景，这是她在保持健康方面的研究和临床兴趣的基础，并为儿童，青少年和年轻人糖尿病患者维持正常的生长，发育和家庭功能。导师团队包括在行为，生物和流行病学领域的专业知识，因为他们涉及到儿科糖尿病的教师。培训活动包括高级研究方法的课程、导师的教学指导和参加研究研讨会。该奖项的拟议研究计划包括两项研究。研究1是对1型糖尿病青年抑郁症评估方法的研究。此外，通过诊断性访谈，研究1将记录大样本1型糖尿病儿童和青少年中抑郁症的患病率，并记录与抑郁症相关的因素。研究2是对这些青年的抑郁、依从性、血糖和健康结果之间联系的纵向检查。潜在增长模型与中介分析将提供有价值的数据之间的联系，抑郁症，坚持和血糖结果的青年1型糖尿病。这项研究的结果有可能影响1型糖尿病儿童和青少年及其家庭的健康和生活质量。

DESCRIPTION (provided by applicant): The candidate for this K23 Mentored Patient-Oriented Research Career Development Award is a research fellow advancing to a junior faculty position. The candidate's long-term goal is to have an academic research career in pediatric diabetes to develop and enhance effective, empirically-supported methods for improving health outcomes and quality of life for children, adolescents, and their families. Specific short-term career goals to be achieved with this award include: 1) to develop an expertise in research methodologies to better understand the impact of emotional functioning of youth and their families on the management and health outcomes associated with type 1 diabetes, 2) to focus on depression in youth with type 1 diabetes and identify the factors predictive of depression in youth with type 1 diabetes, 3) to delineate modifiable factors for intervention and / or prevention in order to prepare an R01 application with a focus on intervention and prevention of depression in children and adolescents with type 1 diabetes. To achieve these goals, the candidate proposes a five-year training program. The candidate's primary mentor has a strong background in pediatrics and epidemiology that forms the basis for her research and clinical interests in preserving the health, and sustaining normal growth, development, and family functioning for children, adolescents, and young adults with diabetes. The mentorship team includes faculty members with expertise in behavioral, biologic, and epidemiologic areas as they relate to pediatric diabetes. Training activities include coursework in advanced research methodology, didactic instruction from mentors, and participation in research seminars. The proposed research plan for this award includes two studies. Study 1 is an examination of methods for assessing depression in youth with type 1 diabetes. Further, through a diagnostic interview, Study 1 will document the prevalence of depression in a large sample of children and adolescents with type 1 diabetes and document factors associated with depression. Study 2 is a longitudinal examination of the links between depression, adherence, and glycemic and health outcomes of these youth. Latent growth modeling with mediational analyses will provide valuable data on the links between depression, adherence, and glycemic outcomes in youth with type 1 diabetes. Findings from this research have the potential to impact the health and quality of life of children and adolescents with type 1 diabetes and their families.