Clinical Research in Human Fertility

本申请提出了一个为期五年的综合研究、教育和教学计划，以发展人类生育的人口统计学、临床和行为方面的多学科研究技能。这个奖项将。在多学科、多视角的知名科学家的指导下，为申请人提供强化培训和指导。申请的具体目的是：(1)加强候选人的科研训练，研究月经周期受孕概率标志物的临床应用，以实现正常生育和次生育的妊娠；(2)在与人类生育的临床和人口维度相关的人口统计学方法、流行病学方法和行为科学研究方法方面接受深入培训；(3)在人类生育的伦理问题方面接受正式培训。培训计划包括(1)课程作业，(2)研究，(3)参加研讨会，(4)有针对性的教学经验。本研究计划收集数据，观察经证实有生育能力的夫妇的月经周期的最大临床可达到的生育能力，这是了解正常生育和不孕症的重要信息。因此，该研究计划旨在帮助候选人发展技能，方法和学院关系，成为一名独立的职业临床研究者，与多学科研究团队一起研究人类生育。研究计划“生育意识对临床妊娠时间的影响”是一项前瞻性随机试验，该试验将检验一种经证实的确定排卵途径的方法（观察阴道从子宫颈排出粘液）对临床妊娠时间的影响，以及排卵前和排卵后6天内性交行为的分布，通过测量尿液中的LH来确定。该项目将对正常生育能力的夫妇寻求尽可能精确的受孕时间具有直接的临床意义。这也将有助于指导未来的研究更准确地描述生育能力低下和不孕症。这些研究活动，以及对人口统计学方法、流行病学方法、行为科学研究方法和伦理学的高级研究，将为一个成功的、独立的临床研究者提供终身职业所需的专业知识。斯坦福博士的长期目标是在人类生育的临床、人口统计学和行为方面建立一个研究项目。这一目标将通过继续在犹他大学担任教职，与多个学科的同事和学生一起工作来实现。犹他大学是一个主要的研究机构，拥有许多杰出的科学家，为斯坦福博士提供了一个良好的环境来发展他的技能，并获得实现他的目标所需的专业知识。

This application proposes a five-year program integrating research, education, and teaching to develop skills for multidisciplinary research in demographic, clinical and behavioral aspects of human fertility. This award will. provide the applicant with intensive training and mentoring under the guidance of established scientists from multiple disciplines and perspectives. The specific aims of the application are (1) to enhance the candidate's research training to study the clinical application of markers of the probability of conception in the menstrual cycle to achieve pregnancy in normal fecundity and subfecundity; (2) to acquire in-depth training in demographic methods, epidemiologic methods, and behavioral science research methods as they relate to clinical and population dimensions of human fertility, and (3) to obtain formal training in ethical issues in human fertility. The training plan includes (1) course work, (2) research, (3) participation in seminars, (4) and targeted teaching experiences. The research plan collects data to observe the maximum clinically attainable fecundability of the menstrual cycle -in couples of proven fertility, information of importance for understanding normal fertility and infertility. Thus the research plan is designed to help the candidate to develop skills, methods, and collegial relationships needed to become an independent career clinical investigator working with multidisciplinary research teams to study human fertility. The research plan, "Effect of fertility awareness on time to clinical pregnancy," is a prospective randomized trial which will examine the effect of a proven method of identifying the approach of ovulation (the observation of vaginal discharge of mucus from the uterine cervix) on time to clinical pregnancy and distribution of acts of intercourse within a 6-day time period preceding and including ovulation, as determined by the measurement of LH in the urine. The project will be of immediate clinical relevance to couples of normal fertility seeking to time conception as precisely as possible. It will also help guide future research to more precisely describe subfecundity and infertility. The research activities, along with advanced studies of demographic methods, epidemiologic methods, behavioral science research methods, and ethics, will provide the expertise needed for a lifelong career as a successful, independent clinical investigator. Dr. Stanford's long-term goal is to develop a program of research at the end intersection of the clinical, demographic, and behavioral aspects of human fertility. This goal will be achieved by continuing and advancing in a faculty role at the University of Utah, working with colleagues and students in multiple disciplines. The University of Utah is a major research institution with many distinguished scientists which offers an excellent environment for Dr. Standford to develop his skills and gain the expertise needed to accomplish his goals.