NEW STRATEGIES FOR IMPROVED IMPRINTED POLYMERS

描述：（主要研究者摘要）分子印迹聚合物 是高度交联的有机基质，其可以容易地合成， 对多种分子、大分子、 甚至是细胞。提出了一种新的策略，以提高应用 分子印迹聚合物（MIPs）的选择性。选择性 印迹聚合物的后修饰导致材料具有更多的 其结合位点之间的均一性和选择性。其原理是 选择性地结合低亲和力位点，使得所得MIP具有更高的 总体结合亲和力和选择性。这一战略不同于以往的 试图改善MIP的性质，这些MIP都依赖于 优化压印工艺。对卫生领域的好处将 是更高纯度的药物和药品，以及可以 针对特定的分析物进行定制。

DESCRIPTION: (Principal Investigator's Abstract) Molecularly imprinted polymers are highly crosslinked organic matrixes that can be readily synthesized to have binding affinity and selectivity for a wide range of molecules, macromolecules and even cells. Proposed is the application of a novel strategy to improve the selectivities of molecularly imprinted polymers (MIPs). Selective post-modification of the imprinted polymers leads to a material with more homogeneity and selectivity among its binding sites. The principle is to selectively inactivate low affinity sites so that the resulting MIP has higher overall binding affinity and selectivity. This strategy differs from previous attempts to improve the properties of MIPs which have all relied on optimization of the imprinting process. The benefits to the health field will be drugs and pharmaceuticals of higher purity and inexpensive sensors that can be tailored to particular analytes.