MOVEMENT ORGANIZATION DYSFUNCTION IN PARKINSONS

虽然近年来帕金森氏病的研究已经取得了进展，但该病的发病机制仍不清楚。这个项目的主要目标是量化帕金森患者复杂的多关节运动是如何受损的，从而更好地了解运动控制原则是如何受损的。我们关于帕金森病患者的工作假设是，他们在复杂动作方面的困难很大程度上是由于他们无法协调身体各部分。我们使用躯干辅助抓取任务，并在速度、精度、分段排序和视觉反馈限制的情况下分析躯干、手臂和孔径同步。我们将分析身体分段同步、相对定时、空间不变性和协同效应。总而言之，这些实验的结果将使我们更好地理解PD如何在复杂动作的执行过程中影响运动协调模式。比较帕金森氏症患者的“关”和“开”状态，可能有助于确定协调障碍是否具有共同的左旋多巴基础。所提出的实验是系统的、新颖的，并使用了经过验证的方法。拟议的研究应该促进对指导正常受试者多关节运动协调的基本原则的理解。它还将增加对帕金森氏症患者在使用这些原则时受到限制的方式的理解。四个实验的结果应该对基础神经科学家和临床科学界都有用，缩小了神经机制基础知识和治疗干预之间的差距。

While advances in Parkinson's disease have been established in recent years, the pathogenesis of the disease is still not well understood. The primary goal of this project is to quantify how complex multijoint movement is impaired in Parkinsonian patients, thereby providing a better understanding of how motor control principles are compromised. Our working hypothesis concerning PD patients is that much of their difficulty with complex movements arises from their inability to coordinate body segments. We use a trunk-assisted prehension task and analyze trunk, arm, and aperture synchronization when speed, accuracy, sequencing of segments, and visual feedback constraints are imposed. We will analyze body segment synchronization, relative timing, spatial invariance, and synergies. Collectively, the results from these experiments will allow us to better understand how PD affects movement coordination patterns during the performance of complex actions. Comparisons of 'off' vs. 'on' states in Parkinson's disease patients may help determine if coordination impairments share a common levodopa basis. The experiments proposed are systematic, novel and use proven methodology. The proposed research should advance understanding of the fundamental principles that guide the coordination of multijoint movements in normal subjects. It will also increase understanding of the ways in which Parkinson's disease patients are restricted in the use of these principles. The results from four experiments should be useful to both the basic neuroscientist and clinical science communities, reducing the gap between fundamental knowledge of neural mechanisms and therapeutic intervention.