Identification of regulatory genomic networks underlying skin ageing

要破译哪些mRNA或表观遗传学变化是随着年龄的增长而导致衰老的，而不是衰老的后果，是极其困难的。然而，与衰老特征相关的DNA序列变异可能是因果关系，因为遗传变异不会随着年龄的变化而变化。遗传变异如何精确地影响附近基因和潜在下游靶点的调控需要进一步研究。因此，解开与衰老相关的遗传变异相关的表观遗传和表达途径的复杂网络，有助于确定因果基因变异如何影响细胞中与衰老相关的过程。

Deciphering which mRNA or epigenetic changes with age contribute to ageing rather than are aconsequence of ageing is extremely difficult. However, DNA sequence variants that associate with ageing traits are likely to be causal, because genetic variants do not change with age. How genetic variants precisely affect regulation of nearby genes and potential downstream targets needs further study. Hence, unravelling the complex network of epigenetic and expression pathways associated with ageing-related genetic variation is useful in determining how causal gene variants influence age-related processes in cells.