Application of Deep Learning to understand neurodegenerative diseases using clinical optical imaging

这是一个博士研究项目，研究深度学习技术，使用基于荧光的单分子和超分辨率图像来了解神经退行性疾病，如阿尔茨海默病和帕金森病。该项目将专注于淀粉样蛋白沉积在大脑中的积累（帕金森病的a-突触核蛋白），这是由可溶性蛋白质错误折叠和聚集成不溶性沉积物/聚集体的过程产生的。为了获得这一信息，我们将调查其在人脑脊液（SFC）中的存在。该项目提案将符合epsrc资助的“Proteus”跨学科研究合作（见：Proteus .ac）。英国)-由Heriot-Watt大学和爱丁堡大学与Matthew Horrocks博士（ue，化学学院）http://www.horrockslab.org/合作。

This is a PhD research project in the investigation of deep learning techniques using fluorescence-based single-molecule and super-resolution images to understand neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. The project will be focused on the accumulation of amyloid deposits in the brain (a-synuclein for Parkinson's disease), which are created by a process of misfolding and aggregation of soluble proteins into insoluble deposits/aggregates. To access this information, we will investigate its presence in human cerebrospinal fluid (SFC).The project proposal will be in line with the EPSRC-funded "Proteus" interdisciplinary research collaboration (see: proteus.ac.uk) - a collaboration involving Heriot-Watt University, and the Universities of Edinburgh, working with Dr Matthew Horrocks (UoE, school of chemistry) http://www.horrockslab.org/.