Neurobehavioral correlates of bipolar disorder

描述（由申请人提供）：双相情感障碍（BD）的特征是情绪、认知和运动活动水平的周期性不稳定。心理生理学数据表明，这种不稳定性可能是由时间同步和时间在毫秒级的分析干扰。这些缺陷包括较差的神经同步，延迟处理，反应幅度降低，更大的受试者内的心理生理反应的变异性。本研究的目的是：（1）区分双相情感障碍中时间处理和协调的状态和特质相关神经行为指标;（2）确定这些指标与临床症状和认知表现的关系;（3）测试这些神经行为指标是否可以预测后续结果。在一项横断面研究中，将使用三种神经行为方案评估I型双相情感障碍患者时间处理的功能完整性。高频EEG夹带将用于测试听觉神经回路频率响应。眨眼经典条件反射将测试脑干和小脑的计时电路。听觉P300潜伏期将用于评估认知处理速度和变异性。来自这些任务的措施产生的时间处理（频率响应，相位同步，处理速度，响应变异性）的动态功能的措施，是敏感的大脑结构（小脑，颞叶皮层）和神经递质系统（多巴胺，GABA）涉及跨时间的认知和情感过程的调节。一年的重新测试将确定观察到的异常随时间的持续性。纵向多变量方法将测试入组时神经行为缺陷与随后的功能和症状结局之间的关联。这些结果将表征双相情感障碍中的时间处理障碍，识别与疾病相关的潜在神经行为内表型，并确定这些神经行为异常是否可预测疾病的结局。

DESCRIPTION (provided by applicant): Bipolar disorder (BD) is characterized by cyclic instability in mood, cognition, and motor activity levels. Psychophysiological data suggests that this instability may be paralleled by disturbances of temporal synchronization and timing at the millisecond scale of analysis. These deficits include poorer neural synchronization, delayed processing, reduced response amplitude, and greater within-subject variability in psychophysiological responses. The aims of this study are to: (1) differentiate state and trait related neurobehavioral measures of temporal processing and coordination in bipolar disorder; (2) determine the relationship of these measures to clinical symptoms and cognitive performance; and (3) test whether these neurobehavioral measures predict subsequent outcomes. In a cross-sectional study, the functional integrity of temporal processing in Type I bipolar disorder will be evaluated using three neurobehavioral protocols. High frequency EEG entrainment will be used to test auditory neural circuit frequency response. Eye-blink classical conditioning will test brainstem and cerebellar timing circuits. Auditory P300 latency will be used to evaluate cognitive processing speed and variability. Measures derived from these tasks yield dynamic functional measures of temporal processing (frequency response, phase synchronization, processing speed, response variability) and are sensitive to brain structures (cerebellum, temporal cortex) and neurotransmitter systems (dopamine, GABA) implicated in the regulation of cognitive and affective processes across time. One year test-retests will determine the persistence of observed abnormalities across time. Longitudinal multivariate methods will test the association between neurobehavioral deficits at entry and subsequent functional and symptomatic outcomes. These results will characterize disturbances of temporal processing in bipolar disorder, identify potential neurobehavioral endophenotypes associated with the illness, and determine whether these neurobehavioral abnormalities are predictive of outcomes in the disorder.