Metal-, Catalyst-, Light- and Electrolysis-Free Decarboxylative C-H Functionalisation of Heterocycles

这是一个化学博士研究项目。我们的目标是扩展我们的可持续方法，以开发更多药学相关杂环的可扩展的后期C-H官能化。在我们的原理验证工作中，我们主要基于异喹啉的优化研究。在这个建议中，我们将调查的CH官能化的重要类别的杂环，这不是我们的证明的原则研究的重点，例如嘌呤和唑。我们将对烷基化、酰化和氨甲酰化反应进行全面的优化和底物范围研究，并将展示克级反应以及后期C-H官能化，以展示可扩展性和官能团耐受性。该提案属于EPSRC合成有机化学研究领域。

This is a PhD research project in Chemistry. We aim to extend our sustainable methodology to develop scalable, late-stage C-H functionalisations of more pharmaceutically relevant heterocycles. In our proof-of-principle work, we predominantly based our optimisation studies on isoquinolines. In this proposal, we will investigate the C H functionalisations of important classes of heterocycles, which were not the focus of our proof-of-principle study, for example purines and azoles. Full optimisation and substrate scope studies will be carried out on the alkylation, acylation as well as carbamoylation reactions, and gram-scale reactions as well as late-stage C-H functionalisations will also be demonstrated to showcase the scalability and functional group tolerance.This proposal lies within the EPSRC research area of synthetic organic chemistry.