Streptococcal Inactivator in Human Chemoattractants

超出提供的空间。这个项目是试图了解的机制，A组Streptococcus调制主机防御。这些链球菌已经进化出蛋白质，包括破坏C5a的C5a肽酶，C5a是吸引保护性吞噬细胞到感染组织的重要早期信号。最近发现，肽酶也是一种纤维连接蛋白和细胞结合蛋白已成为一个重要的新焦点。计划使用鼻内和皮下小鼠感染模型，评价这些活性相对于肽酶活性在毒力中的重要性。认识到青霉素往往不能消除A组链球菌从患病儿童的喉咙和最近的严重并发症与链球菌感染的复苏，促使工业界和国家卫生研究院大力开发预防性疫苗。C5a肽酶是疫苗开发的主要焦点，增加了了解其在毒力中的作用及其对宿主防御的影响的需要。新的数据表明，CSa肽是链球菌在鼻相关淋巴组织中成功定植和持续存在所需的。性能现场=

EXCEEDTHESPACEPROVIDED. This project is an attempt to understand the mechanism by which group A streptococcus modulates host defenses. These streptococci lave evolved proteins including the C5a peptidase that destroys C5a, an important early signal that attracts protective phagocytes to infected tissue. The recent discovery that the peptidase is also a fibronectin and cell binding protein has become a significant new focus. Experiments are planned to evaluate the importance of these activities, relative to peptidase activity in virulence using intranasal and subdermal mouse models of infection. Recognition that penicillin often fails to eliminate group A streptococci from throats of ill children and the recent resurgence of serious complications associated with streptococcal infections, has prompted an intense effort to develop preventive vaccines by industry and NIH. The C5a peptidase is a major focus of vaccine development, increasing the need to learn more about its role in virulence, and its impact on host defenses. New data indicates that the CSa peptide required for successful colonization and persistence of streptococci in nasal associated lymphoid tissue. PERFORMANCE SITE ========================================Section End===========================================