VISCERAL ADIPOSITY AND CVD RISK IN WOMEN

描述：肥胖与发病率和死亡率增加有关。 随着肥胖症的患病率和严重程度的增加， 发病年龄增加，发病年龄下降。也很明显， 脂肪的位置可能在确定相关风险方面发挥重要作用， 肥胖症腹腔内脂肪已被证明具有特别不利的 与心血管危险因素有关的后果。有趣的是 许多研究表明，总体肥胖的影响， 因种族而异。对于每一个单位的肥胖增加，黑人似乎有 血压和甘油三酯的增加较少， 高密度脂蛋白胆固醇水平这种种族差异 肥胖与心血管风险状态的关系可能与 脂肪分布的差异。假设对于给定的 水平和增加全身脂肪（DEXA测量）黑人妇女将有 更少的腹内脂肪（通过磁共振成像测量）。 拟议的队列研究将包括650名黑人和白色妇女， 作为NHLBI增长的一部分，从9岁或10岁起就被跟踪， 健康研究。受试者将在23岁时接受研究，并在25岁时再次接受研究。在 每次检查，受试者将测量总脂肪（DEXA）， 腹内脂肪（MRI）、空腹脂质和脂蛋白、胰岛素和 血糖、血压和左心室质量（超声心动图）。在 此外，青春期成熟的时间和饮食中脂肪的摄入， 蔗糖将被评价为腹内脂肪的潜在决定因素 使用之前从9岁到22岁收集的数据。研究 这一组群提供了一个独特的机会，以评估是否差异， 腹腔内脂肪沉积与种族差异有关， 肥胖与心血管危险因素的关系。它还将 允许评估儿童和青少年成人的决定因素 腹内肥胖这次调查的结果可能会提供 深入了解预防腹内脂肪堆积和最终 降低患心血管疾病的风险。

DESCRIPTION: Obesity is associated with increased morbidity and mortality. Concern about obesity has increased as the prevalence and severity have increased and the age of onset has decreased. It has also become clear that the location of fat may play an important role in determining the risk associated with obesity. Intra-abdominal fat has been shown to have particularly adverse consequences related to cardiovascular risk factors. Of interest is the fact that a number of studies have shown that the impact of overall adiposity differs by race. For each unit increase in adiposity, blacks appear to have less of an increase in blood pressure and triglycerides and less of a decrease in HDL cholesterol compared to whites. This racial difference in the relationship of adiposity to cardiovascular risk status may be related to differences in the distribution of fat. It is hypothesized that for a given level and increase in total body fat (measured by DEXA) black women will have less intra-abdominal fat (measured by magnetic resonance imaging). The proposed cohort study will be comprised of 650 black and white women who have been followed since age nine or 10 years as part of the NHLBI Growth and Health Study. Subjects will be studied at age 23 and again at age 25 years. At each examination, subjects will have measurement of total fat (DEXA), intra-abdominal fat (MRI), fasting lipids and lipoproteins, insulin and glucose, blood pressure, and left ventricular mass (by echocardiography). In addition, the timing of pubertal maturation and dietary intake of fat and sucrose will be evaluated as potential determinants of intra-abdominal fat using data previously collected from age nine years to age 22 years. Study of this cohort provides a unique opportunity to evaluate whether differences in deposition of intraabdominal fat are related to racial differences in the relationship between adiposity and cardiovascular risk factors. It will also allow evaluation of childhood and adolescent determinants of adult intra-abdominal adiposity. The results of this investigation may provide insight into the prevention of intra-abdominal fat accumulation and ultimate lowering of risk for cardiovascular disease.