DOSE-RESPONSE TO EXERCISE IN WOMEN AGED 45-75 YEARS

老年女性运动剂量反应的主要目标 45-75岁(DRAW)是为了调查不同剂量的 运动对心肺功能及心血管危险因素的影响 疾病。参与者将久坐不动、超重或肥胖、绝经后 有正常高血压或I期高血压的女性，因此 心血管疾病的风险处于中等高危状态。共有450名妇女(35人 百分比将来自少数群体)将被随机分配给对照 组(N=100)或3个运动组中的1个(N=150为最低运动量 而在两个最高运动组中每组100人)。女性被分配到 运动组将锻炼6个月，能量消耗分别为4、8或 每周12千卡/公斤。这些运动剂量代表了公众的共识 最近发布的指南中对身体活动的健康建议 来自美国公共卫生服务、美国心脏协会和 美国运动医学院(每周8千卡/公斤)，剂量为50 低于(每周4千卡/千克)的百分比超过50%(每周12千卡/千克) 共识剂量。所有女性都将以最大摄氧量的50%进行锻炼。演练 会议将在实验室进行，每个会议都有单独的监督 会议并严格控制频率、持续时间和强度。这将是 提供已完成的确切运动量的详细记录。 主要观察指标为最大摄氧量和静息收缩压。其他 心血管疾病风险因素，心理社会变量，与健康相关 生活质量、身体成分和脂肪分布是次要结果。 其他二级分析将包括对观察到的程度的关注 剂量-反应效应由健康、种族、 风险因素，或年龄。评估将在基线和6个月内进行。这个 研究将提供关于(1)结果变化模式的信息 由几个运动量的每一个产生的，(2)是否在 低于目前公认的剂量有任何好处，(3)是否执行 运动量超过共识剂量的运动量更大(或按比例更大) 健康益处，以及(4)久坐女性的特征 可能从各种运动量中受益。

The primary goal of the Dose-Response to Exercise in Women Aged 45-75 Years (DREW) is to investigate the effects of different amounts of exercise on both cardiorespiratory fitness and risk factors for cardiovascular disease. Participants will be sedentary, overweight or obese, postmenopausal women who have high normal blood pressure or Stage I hypertension, and thus are at moderately high risk for cardiovascular disease. A total of 450 women (35 percent will be from minority groups) will be randomly assigned to a control group (N=100) or to 1 of 3 exercise groups (N=150 for the lowest exercise dose and 100 each in the two highest exercise groups). Women assigned to the exercise groups will exercise for 6 months at energy expenditures of 4, 8, or 12 kcal/kg per week. These exercises doses represent the consensus public health recommendation for physical activity from recently published guidelines from the U.S. Public Health Service, American Heart Association, and the American College of Sports Medicine (8 kcal/kg per week) and at doses 50 percent below (4 kcal/kg per week) 50 percent above (12 kcal/kg per week) the consensus dose. All women will exercise at 50 percent of VO2 max. The exercise sessions will take place in the laboratory, with individual supervision of each session and strict control of frequency, duration, and intensity. This will provide thorough documentation of the exact amount of exercise completed. Primary outcome measures are VO2 max and resting systolic blood pressure. Other cardiovascular disease risk factors, psychosocial variables, health-related quality of life, body composition, and fat distribution are secondary outcomes. Other secondary analyses will include a focus on the extent to which observed dose-response effects are modified by baseline levels of fitness, ethnicity, risk factors, or age. Assessments will take place at baseline and 6 months. The research will provide information about (1) patterns of change in outcomes produced by each of several exercise doses, (2) whether performing exercise at less than the current consensus dose has any benefit, (3) whether performing more exercise than the consensus dose has greater (or proportionally greater) health benefits, and (4) the characteristics of sedentary women who are most likely to benefit from various exercise doses.