Study of Lead Exposure & Outcomes Amongst Children in C*

超出所提供的空间。本修订提案中的研究将主要在印度进行，作为NIH拨款#R01 ES07821的延伸。在印度，铅接触是一个重大的环境健康问题。在印度还没有进行直接研究来调查铅暴露对神经行为发育等结果的影响。我们建议在提议的PI作为高级富布赖特学者工作期间发起的合作努力的基础上，与印度泰米尔纳德邦的Sri Ramachandra医学院和金奈（以前称为马德拉斯）研究所的同事合作，研究在金奈地区特定公立学校就读的750名4-6岁儿童。这些学校将被选择代表城市中交通和工业方面的高、高、低、低、低的区域。我们将测量每个儿童的血铅水平和乳牙脱落情况；评估视觉空间功能（使用Raven's Progressive Matrices）、视觉运动功能（使用宽范围视觉运动能力评估）、行为（使用Conners' Rating Scale-Revised）和智商（使用Binet-Kamath测试）；采集血液提取DNA，并对氨基乙酰丙酸脱水酶（ALAD）、载脂蛋白E和转铁蛋白基因的多态性进行基因分型；收集协变量的数据。有了这些信息，我们将描述铅暴露和暴露剂量关系，并测试关于铅剂量与神经行为结果关系的特定假设，以及遗传多态性对这些相同关系的修饰作用。本研究有望提供有关铅毒性的新科学信息，以及铅暴露对印度城市儿童神经行为发育影响的重要信息。它还将成为美国和印度之间建立环境卫生合作研究的中心。网站性能 ======================================== 节结束 ===========================================

EXCEED THE SPACE PROVIDED. The research in this revised proposal will be performed primarily in India as an extension of NIH grant #R01 ES07821. Lead exposure poses a major environmental health problem in India. No direct studies have yet been performed in India to investigate the impact of lead exposure on outcomes such as neurobehavioral development. We propose to build upon a collaborative effort initiated during the proposed PI's work as a Senior Fulbright Scholar and work with colleagues at the Sri Ramachandra Medical College and Research Institute of Chennai (formerly known as Madras), Tamil Nadu, India, to study 750 children aged 4-6 attending specific public schools in the area of Chennai. These schools will be chose to represent areas of the city that are high-high, high-low, low-high, and low-low with respect to traffic and industry. For each child we will measure levels of lead in blood and shed primary teeth; assess visuospatial function (using Raven's Progressive Matrices), visuomotor function (using the Wide Range Assessment of Visual Motor Abilities), behavior (using Conners' Rating Scale-Revised), and IQ (using the Binet-Kamath test); collect blood for the extraction of DNA and genotyping for polymorphisms of the aminolevulinic acid dehydratase (ALAD), apoliproprotein E, and transferrin genes; and collect data on covariates. With this information we will describe lead exposure and exposure-dose relationships and test specific hypotheses on the relationship of lead dose to neurobehavioral outcomes and the modifying effect of genetic polymorphisms on these same relationships. This research promises to provide novel scientific information on lead toxicity as well as important information on the impact of lead exposure on pediatric neurobehavioral development in urban India. It will also serve as a nidus for building collaborative environmental health research between the U.S. and India. PERFORMANCE SITE ========================================Section End===========================================