Molecular basis of neurotransmission - cryo-EM structural and functional investigation of the human serotonin receptor in a lipid environment

对于一只小小的蚊子来说，在一个广阔的世界里找到一个交配的伴侣是一个挑战。就像人类聚会一样，蚊子也会成群结队地寻找配偶。交配群是由数百只蚊子组成的迷人实体;它们每天都在同一个地方发生。扰乱蜂群可能对控制疾病传播蚊子产生重大影响。但是我们对诱导蚊子群集行为的内源性分子机制几乎一无所知。该项目将结合联合收割机遗传学、生理学和药物学技术来识别这些神经通路和阻断它们的潜在策略。

For a tiny mosquito in a wide world, finding a mating partner is a challenge. The same wayhumans gather at parties, mosquitoes aggregate in swarms to find a mate. Mating swarmsare fascinating entities formed by hundreds of mosquitoes; they take place in the samelocations every day. Disrupting swarms could have a major impact on controlling disease transmitting mosquitoes. But we hardly know anything about the endogenous molecularmachinery that induce mosquito swarming behaviour. This project will combine genetic,physiological and pharmaceutical techniques to identify these neurological pathways andpotential strategies to block them.