Training/Cellular/Molecular Mechanisms/Tumor Rejection

描述（由申请人提供）：癌症问题的免疫学解决方案在于我们能够引发有效的、强有力的免疫反应，并具有终身记忆，针对抗原，这些抗原与自身分子并没有太大的不同。肿瘤细胞对免疫细胞的不同且往往具有免疫抑制作用，使问题更加复杂。这个令人兴奋的研究领域继续为在免疫学最新范式中受过良好训练的年轻科学家提供挑战和机会。匹兹堡大学医学院的免疫学教师过去已经成功地培养了许多有才华的研究人员，他们已经在肿瘤免疫学领域产生了重大影响。在该基金的第一个资助期，招募并支持高成就的学员进行与肿瘤免疫学相关的研究。我们建议通过继续开展肿瘤排斥细胞和分子机制的博士前和博士后培训计划，继续招募最优秀和最聪明的人才进入这一研究领域。我们在我们的免疫学研究生培训计划中培养博士生和博士后，这是匹兹堡大学医学院生物医学科学跨学科培训计划的九个培训计划之一。这项培训补助金支持的目标是为学生和研究员提供课程、研究项目、高素质的导师和财政资源，使他们能够：阐明肿瘤特异性免疫启动的基本机制；2. 明确抗肿瘤免疫应答的效应机制；和3。了解建立长期抗肿瘤免疫记忆的要求。我们一直在通过精心策划和组织的课程活动来实现这些目标，并结合项目活动，促进项目教师和学员之间的实质性交流。该项目还努力在其专业的其他重要方面培养研究生和研究员。及时在同行评议稿中报告研究成果，并在国内和国际会议上报告研究成果；2. 向各私人及政府资助机构提交拨款建议；3. 教授与其专业领域相关的课程。

DESCRIPTION (provided by applicant): Immunological solutions to cancer problem lie in our ability to elicit effective, potent immune responses, with life long memory, against antigens that are not much different then self molecules. The problem is compounded by different and often immunosuppressive effects on the immune cells by tumor cells. This exciting field of research continues to provide challenges and opportunities for young scientists well trained in the newest paradigms in immunology. The immunology faculty at the University of Pittsburgh School of Medicine have successfully trained many talented investigators in the past who have already made significant impact in the field of tumor immunology. In the first funding period of this grant, highly accomplished trainees were recruited and supported in their research related to tumor immunology. We propose to continue to recruit the best and the brightest into this area of research through the continuation of our predoctoral and postdoctoral training program in Cellular and Molecular Mechanisms of Tumor Rejection. We train predoctoral students and postdoctoral fellows within our Graduate Training Program in Immunology, one of nine training programs of the Interdisciplinary Training Program in Biomedical Sciences of the University of Pittsburgh School of Medicine. The goals supported by this training grant are to provide students and fellows with courses, research projects, highly qualified mentors and financial resources which will allow them to: 1. Elucidate the basic mechanisms of initiation of tumor-specific immunity; 2. Define the effector mechanisms in the anti-tumor immune response; and 3. Understand the requirements for establishment of long-term antitumor immune memory. We have been accomplishing these goals through well-planned and organized course activities, combined with program activities that promote substantive communication among the program faculty and trainees. The program also strives to train both graduate students and fellows in other important aspects of their profession: 1. Reporting in a timely fashion research results in peer reviewed manuscripts and at national and international meetings; 2. Writing grant proposals to various private and government funding agencies; 3. Teaching in courses related to their field of expertise.