AGEING. WERNER SYNDROME AND PSEUDOCAPILLARIZATION

老年是动脉粥样硬化的主要危险因素，也是世界范围内死亡率和发病率的主要原因。我们发现，肝脏微循环中与年龄相关的变化称为假性毛细血管形成，它提供了一种将衰老与动脉粥样硬化联系起来的机制。内皮细胞中的小孔消失了，这损害了肝脏分解脂肪的能力。治疗和预防年龄相关假性毛细血管形成的新疗法正在开发中。

Old age is the main risk factor for atherosclerosis, which is the main cause of mortality and morbidity in the World. We found age-related changes in the microcirculation of the liver called pseudocapillarization that provide a mechanism linking old age with atherosclerosis. Pores in the endothelium called fenestrations disappear, impairing the ability of the liver to breakdown fats. New therapies to treat and prevent age-related pseudocapillarization are being developed.