Core--(Primate Studies) Radiation countermeasure center

这个项目是多机构辐射对策协会的灵长类研究核心。核心将帮助进行药物研究，以保护受到辐射的人的健康，例如在恐怖袭击涉及“脏弹”或核弹的情况下。由于非人类灵长类动物和人类在基因和功能上高度相似，这种核心资源是候选辐射防护药物的关键成分，在实验环境中，可以向健康的受试者提供辐射(这不能在人类身上进行)。该核心将为正常组织损伤、骨髓恢复和免疫计划提供服务。核心研究人员在非人类灵长类动物的实验使用和临床医学方面拥有独特的技能，包括辐射；兽医医疗 研究领域包括：抑制骨髓的动物的研究和管理；灵长类动物的疾病；辐射损伤的病理学；灵长类动物的血液检测和激素调节；基因技术对灵长类动物模型的适应。核心服务将包括获取和维持无病灵长类动物，将动物暴露在辐射中，实施治疗干预措施以防止辐射损害，以及对非人类灵长类动物的治疗结果进行临床和病理评估，包括尸检和组织收集，并分享辐射反应的基线特征和减轻干预措施的评估。核心还将为灵长类动物提供广泛的数据管理服务 包括数据共享在内的研究。

This project is a Primate Studies Core for a multi-institutional Radiation Countermeasures Consortium.The Core will help conduct studies of drugs that may protect the health of people exposed to radiation, as in the case of a terrorist attack involving a "dirty bomb" or nuclear bomb. Because of the high degree of genetic and functional similarity between nonhuman primates and human beings, this core resource is a critical component of candidate radiation-protective drugs, in an experimental setting under which radiation can be given to healthy subjects (which cannot be done in people). This core will serve programs in Normal Tissue Injury, Bone Marrow Recovery, and Immunity programs. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates including irradiation; veterinary medical care and management of bone-marrow-suppressed animals; diseases of primates; pathology of radiation injury; blood testing and hormonal regulation in primates; and adaptation of genetic techniques to the primate model. Core services will include acquisition and maintenance of disease-free primates, exposure of animals to radiation, administration of therapeutic interventions to prevent radiation damage, and clinical and pathologic assessments of treatment outcomes in nonhuman primates, including post-mortem examination and tissue collection and sharing for both baseline characterization of radiation responses and assessment of mitigating interventions. The Core will also provide extensive data management services for primate studies including data sharing.