Core--Lipids and Chronic Diseases

描述(申请人提供)：血脂和慢性病的总体目标 研究核心：血脂和卡路里的高摄入量与发病率增加和 慢性疾病的严重程度，包括糖尿病、肥胖、某些癌症和心血管疾病(CVD)。由于大量摄入脂肪，脂类代谢会改变，并有助于疾病过程的开始和发展。疾病过程反过来改变新陈代谢，进一步导致更多的并发症。这些疾病最普遍的危险因素和治疗目标之一是血脂异常，众所周知，这会受到饮食的影响。少数群体所有慢性病，特别是前列腺癌(Powell和Meyskens 2001)、糖尿病(Kamel，Rodriguez-Saldana等人)的发病率和发病率高得不成比例。1999)、哮喘(Strunk、Ford等人2002年)，肥胖(包括儿童肥胖(Crawford，Story等人2001年)和心血管疾病(CVD)。来自美国最大的饮食习惯和健康状况调查的观察结果 第三次全国健康和营养检查调查(NHANES)确定老年黑人和墨西哥裔美国妇女和黑人男子患心血管疾病的风险最大(Winkleby，Kraemer等人)。1998年；Sundquist，Winkleby等人。2001年)，与年轻少数民族人群中心血管疾病风险增加的情况相似(Winkleby，Robinson等人)。1999年)。多种心血管疾病危险因素，包括血脂以及饮食脂肪、肥胖、高血压和糖尿病，导致了这些种族差异。

DESCRIPTION (provided by applicant): Overall Objectives of the Lipids and Chronic Diseases Research Core: High intakes of lipids and calories are associated with increased incidence and severity of chronic diseases including diabetes, obesity, certain cancers, and cardiovascular diseases (CVD). As a consequence of high intakes of fat, lipid metabolism is altered and contributes to the initiation and development of disease processes. The disease process in turn alters metabolism further contributing to additional complications. One of the most prevalent risk factors and targets of therapy for these diseases is dyslipidemias, which are known to be affected by diet. Minority populations have disproportionately high incidences and morbidities of all chronic diseases and specifically prostate cancer (Powell and Meyskens 2001), diabetes (Kamel, Rodriguez-Saldana et al. 1999), asthma (Strunk, Ford et al. 2002), obesity (including childhood obesity (Crawford, Story et al. 2001), and cardiovascular diseases (CVD). Observations from the largest survey of dietary habits and health status in the U.S., the Third National Health and Nutrition Examination Survey (NHANES), have established that older black and Mexican American women and black men were at greatest risk for CVD (Winkleby, Kraemer et al. 1998; Sundquist, Winkleby et al. 2001), paralleling the heightened risk of CVD among younger ethnic minority populations (Winkleby, Robinson et al. 1999). Multiple CVD risk factors, including plasma lipids as well as dietary fat, obesity, hypertension, and diabetes, contribute to these ethnic differences.