A Transcutaneous Nanotube Hydrogen Sensor

描述(由申请人提供)：我们建议开发一种基于纳米多孔二氧化钛的室温、经皮氢传感器，能够在潜在干扰气体分析物存在的情况下检测0.1ppm的氢。我们预计，所得到的传感器将被用作绷带，并且足够便宜，可以随时在一次性基础上使用。该项目将建立在合作研究人员在高性能气体传感器、传感器电子学和传感器集成领域的工作基础上。 在第一阶段下要实现的具体目标是：{1}扩展二氧化钛纳米管氢传感器制造技术，以实现对孔尺寸的精确控制，进而确定其氢敏感性。{2}将用于制备纳米多孔二氧化钛和氧化铝的阳极氧化技术扩展到包括SnO2和WO3在内的其他成分。{3}将材料结构和组成与气敏特性相关联，建立了用于确定潜在干扰气体混合物中氢浓度的算法，这些混合气体包括二氧化碳、O2、硝酸、氨和丙酮。{4}根据需要，以电子鼻形式交叉关联不同纳米多孔金属氧化物传感器的响应，以消除干扰气体的影响，从而能够在低于1ppm的水平下对空气中和室温下的氢气进行精确的经皮测量。将所需的数据逻辑处理电子鼻算法减少到商业上可用的数据采集系统芯片(约25美元)，占地面积为2厘米x 2厘米。 在第二阶段，与宾夕法尼亚州立儿童医院(好时)新生儿重症监护病房的D.James Kendig合作，经皮氢传感器将被应用于临床确定新生儿坏死性小肠结肠炎的发病时间，这是一种病因不明的破坏性疾病，会导致早产儿小肠和大肠壁的缺血和坏死。

DESCRIPTION (provided by applicant): We propose to develop a room temperature, transcutaneous hydrogen sensor based upon nanoporous-titania capable of 0.1ppm hydrogen detection in the presence of potentially interfering gas analytes. We anticipate that the resulting sensor will be applied as a bandage, and be inexpensive enough to be readily used on a disposable basis. The project will build upon work of the co-investigators in the fields of high performance gas sensors, sensor electronics, and sensor integration. The specific enabling objectives to be pursued under Phase I are: {1} Extend the TiO2-nanotube hydrogen sensor fabrication technique to enable precise control over pore dimensions which in turn determine its hydrogen sensitivity. {2} Extend the anodization technique established for fabricating nanoporous TiO2 and AI203 to additional compositions including SnO2 and WO3. {3} Correlate material structures and composition with gas sensing properties, establishing algorithms for the determination of hydrogen concentration within potentially interfering gas mixtures that include CO2, O2, nitric acid, ammonia and acetone. {4} As needed, cross correlate the response of different nanoporous metal oxide sensors in an e-nose format to eliminate the effect of interfering gases enabling precise transcutaneous measurement of hydrogen, in air and at room temperature, at sub 1 ppm levels. Reduce the needed data logic processing e-nose algorithms to a commercially available data acquisition system chip (about $25) having a 2 cm x 2 cm footprint. During Phase II in collaboration with D. James Kendig of the Neonatal Intensive Care Unit at the Penn State Children's Hospital (Hershey, PA) the transcutaneous hydrogen sensor will be applied to facilitate clinical determination of the onset of neonatal necrotizing enterocolitis, a devastating disease of uncertain etiology which causes ischemia and necrosis of the small and large intestinal walls of preterm infants.