SEARCH for Diabetes in Youth Coordinating Center

描述（由申请人提供）：本提案描述了“青年糖尿病研究搜索”第二阶段数据协调中心（CoC）的开发、实施和维护。SEARCH研究CoC是由维克森林大学医学院（WFUSM）的一组研究人员提出的，以响应疾病控制和预防中心题为“青少年糖尿病的发病率、自然史和生活质量”的RFA （RFA- dp -05-069）。自2001年以来，WFUSM一直担任搜索研究第一阶段的CoC，完全有能力承担这一职责。本研究是一项六个中心的研究，调查了2001年以来0-19岁青少年糖尿病的患病率、发病率和临床表现，包括糖尿病类型、种族、性别和年龄。WFUSM SEARCH CoC目前正在存储和分析来自6个搜索中心（南卡罗来纳州、辛辛那提、西雅图、南加州、科罗拉多州、夏威夷）的1万多名青少年的数据，这些数据代表了2001年的流行病例和2005-2005年的意外病例。

DESCRIPTION (provided by applicant): This proposal describes the development, implementation and maintenance of a data coordinating center (CoC) for the second phase of the SEARCH for Diabetes in Youth Study. The SEARCH study CoC is being proposed by a team of investigators from the Wake Forest University School of Medicine (WFUSM) in response to an RFA from the Centers for Disease Control and Prevention entitled, "Incidence, Natural History, and Quality of Life of Diabetes in Youth" (RFA-DP-05-069). WFUSM is well positioned to serve in this capacity, having served as the CoC for the first phase of the SEARCH study since 2001. This study was a six-center study examining the prevalence, incidence, and clinical presentation of diabetes among youth 0-19 years by diabetes type, ethnicity, gender and age, since 2001. Data from over 10,000 youth, representing prevalent cases in 2001 and incident cases in 2005-2005 at the six SEARCH centers (South Carolina, Cincinnati, Seattle, Southern California, Colorado, Hawaii), is currently being stored and analyzed by the WFUSM SEARCH CoC. The WFUSM will provide statistical and operational support to address the following study aims proposed by the original SEARCH clinic sites for the second phase of SEARCH: (1) to prospectively ascertain newly diagnosed (2006-2008) incident diabetes cases in children/youth <20 years of age and collect data that permits estimation of temporal trends in diabetes incidence by age-group, gender, race/ethnicity and diabetes type for the period 2002-2008; (2) to conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2003-2005 in order to document the evolution of newly diagnosed diabetes according to clinical and biochemical factors and characterize the evolution of key risk factors for diabetes complications, according to diabetes type and race/ethnicity; (3) to assess the impact of quality of diabetes care in youth on short-and long-term outcomes including quality of life by completing analytic work initiated in SEARCH as described in the Quality of Care Roadmap and expanding the scope of quality of care assessment initiated in SEARCH in order to explore the interrelationships of patient characteristics, important domains of health care with outcomes, including glycemic control, satisfaction with care, receipt of recommended services, complications, and quality of life; and (4) to develop and validate simple and low-cost case definitions and classifications of diabetes types in youth that can be used for public health surveillance. Additionally, the WFUSM CoC will develop a plan to secure a central laboratory for the SEARCH study for storage and analysis of blood and urine sample and storage of DNA for ancillary studies. This phase of the SEARCH study will build on the knowledge gained in the first phase of the study, and will provide valuable clinical and public health information to address the growing problem of childhood diabetes.