INFORMATICS TRAINING FOR BRAZILIAN VECTOR AND PARASITIC*

描述(由申请人提供)：本提案是佐治亚大学、乔治华盛顿大学、里约热内卢的奥斯瓦尔多·克鲁斯-菲奥克鲁斯研究所和巴西贝洛奥里藏特的雷内·拉乔-菲奥克鲁斯研究中心之间的合作培训伙伴关系。CPqRR目前有15个实验室和3笔由NIH资助的赠款(一笔关于新发和再发疾病的培训赠款，一笔关于血吸虫病宿主遗传相关性的ICIDR赠款，以及一笔关于巴西农村心脏病遗传结构的赠款“。这项培训提案的目标是在CPqRR在生物信息学、流行病学和分子进化领域建立可持续的核心基础设施，以补充国家卫生研究院资助的现有研究，并促进在其他实验室进行的研究。CPqRR的研究重点是热带寄生虫、它们的媒介和它们的宿主。这些生物包括：恶性疟原虫、克鲁兹锥虫、弓形虫、曼氏血吸虫、按蚊、生物和人类。这项建议旨在通过启动一项为期5年的有针对性的培训计划来满足CPqRR的需求，该计划包括CPqRR 15个实验室中许多实验室的博士后和博士后学生。高级培训将通过讲习班、课程、短期和长期培训在巴西国内和国外进行。培训将涉及合作研究项目，这些项目源于CPqRR的需要，侧重于血吸虫病的几个方面。这一培训的统一项目将是创建一个血吸虫基因组关系数据库，该数据库由CPqRR收存并提供服务。该数据库将保存CPqRR生成的转录组数据和流行病学数据。分子进化培训将侧重于血吸虫媒介、生物疟疾和流行病学/生物统计数据，并将从现有资助项目中得出和分析这些数据。从这次培训和实施演习中获得的技术和知识将直接适用于对其他寄生生物的研究。我们将积极寻找有强烈意愿的合格人员参加培训，并将其新获得的专业知识贡献给当地卓越培训中心的延续。

DESCRIPTION (provided by applicant): This proposal represents a collaborative training partnership between researchers at the University of Georgia, the George Washington University, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro and the Centro de Pesquisas Rene Rachou - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 15 laboratories and 3 funded NIH grants (A training grant in emerging and re-emerging diseases, an ICIDR grant on host genetic correlates in schistosomiasis and a grant on the genetic architecture of heart disease in rural Brazil". The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium falciparum, Trypanosoma cruzi, Toxoplasma gondii, Schistosoma mansoni, Anopheles, Biomphalaria and Humans. This proposal is designed to meet the needs of the CPqRR by initiating a 5-year targeted training program that involves pre-and post-doctoral students from many of the 15 laboratories at the CPqRR. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the creation of a Schistosoma genome relational database housed and served from the CPqRR. This database will house the transcriptome data and epidemiological data being generated by the CPqRR. Molecular evolution training will focus on the Schistosome vector, Biomphalaria and epidemiological/ biostatistical data will be derived and analyzed from existing funded projects. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a local training center of excellence.