Sensors for Biofilms and Bioburden in Wound Dressings

伤口敷料用于加速伤口愈合过程，同时防止感染。理想情况下，应该让伤口在不受干扰的情况下愈合，但伤口状况需要定期评估，以检查感染并进行快速干预。尽管有抗菌敷料，但它们的使用可能是有害的，这些敷料通常提供亚治疗水平的抗菌药物，因此可能会减缓伤口愈合。该项目旨在通过开发智能敷料来解决这些问题，这种敷料可以实时检测感染，并允许更好的伤口管理。在项目期间，我们将开发生物模型来重现感染伤口，并测试一系列传感器技术来检测感染。然后，我们将开发基于最适合应用的最合适的传感器技术（包括读出）的智能穿衣原型，同时考虑到制造和装配限制。总之，该项目有可能对伤口管理产生积极影响。

Wound dressings are used to speed up the wound healing process while preventing infections. Ideally, wounds should be allowed to heal undisturbed, however the status of the wound needs to be evaluated regularly, to check for infection and enable rapid intervention. Even though antimicrobial dressings are available, their use can be detrimental and these dressings are often delivering antimicrobials at sub-therapeutic levels and therefore may be slowing down wound healing. The project aims to solve these issues through the development of smart dressing that can detect infections in real-time and allow for better wound management. During the project, we will develop biological models to recapitulate infected wounds and test a range of sensor technologies to detect infection. We will then develop a smart dressing prototype based on the most appropriate sensor technology (including read-out) that is most suited for the application, taking manufacturing and assembly constraints into consideration. In summary, the project has the potential to have a positive impact on wound management.