Center for Integrative Studies of Aging

描述(由申请人提供)： 美国的老龄化增加了对老龄化和与年龄相关的疾病的研究的重要性，如阿尔茨海默氏症、帕金森氏症、中风和癌症。在这一领域的成功将需要NIH路线图中描绘的被确定为国家生物医学研究事业关键的相同方法：新的发现途径，如基因组学和蛋白质组学；跨学科研究团队；以及提高基本发现转化为临床进展的效率。 巴克年龄研究所是美国唯一一个致力于衰老生物学和与年龄相关疾病的基础研究的长期机构。我们的长远目标是开发早期诊断标记和治疗方法，以预防或延迟与年龄相关的疾病，从而延长健康的寿命，促进长寿，并提高老年人的生活质量。 我们请求支持，帮助为新实验室扩建11,700平方英尺的现有外壳空间。拟议的计划将使巴克研究所能够实现其目标，招聘8名新的首席研究人员，从而实现关键的科学家数量；增加长寿遗传学、与年龄相关的DNA损伤及相关领域的专业知识；集中研究人员在连续空间采用不同方法进行老龄化研究；扩大基因组和蛋白质组核心设施；加强研究培训计划；发展发现翻译股，以提供高通量筛选和简化基础研究到临床的翻译；并为巴克研究所研究人员之间的合作创造新的机会。

DESCRIPTION (provided by applicant): The "graying" of America has increased the importance of research on aging and age-related diseases, such as Alzheimer's disease, Parkinson's disease, stroke and cancer. Success in this arena will require the same approaches that have been identified as key to the national biomedical research enterprise, as delineated in the NIH Roadmap: new pathways to discovery, such as genomics and proteomics; interdisciplinary research teams; and increasing the efficiency with which basic discoveries are translated into clinical advances. The Buck Institute for Age Research is the only flee-standing institute in the United States devoted to basic research on the biology of aging and age-related diseases. Our long-term objective is to develop early diagnostic markers and therapies to prevent or delay age-associated diseases, so as to extend the healthy years of life, promote longevity and enhance the quality of life at advanced ages. We request support to help build out 11,700 square feet of existing shell space for new laboratories. The proposed plan would enable the Buck Institute to accomplish its aims to recruit 8 new principal investigators and thereby achieve a critical mass of scientists; add expertise in genetics of longevity, age associated DNA damage, and related fields; concentrate investigators employing diverse approaches to aging research in contiguous space; expand genomics and proteomics core facilities; enhance research training programs; develop a Discovery Translation Unit to provide high-throughput screening and streamline translation of basic research to the clinic; and create new opportunities for collaboration among Buck Institute investigators.