INFORMATICS TRAINING- BRAZILIAN VECTOR/PARASITIC DISEASE

描述（由申请人提供）：该提案代表了格鲁吉亚大学、乔治华盛顿大学、里约热内卢Oswaldo Cruz-FIOCRUZ研究所和巴西贝洛奥里藏特Rene Rachou研究中心的研究人员之间的合作培训伙伴关系。CPqRR目前有15个实验室和3个国家卫生研究院资助的赠款（新出现和重新出现疾病的培训赠款，ICIDR关于血吸虫病宿主遗传相关性的赠款和巴西农村心脏病遗传结构的赠款）。本培训提案的目标是在CPqRR建立生物信息学、流行病学和分子进化领域的可持续核心基础设施，以补充现有NIH资助的研究，并促进其他实验室进行的研究。CPqRR的研究重点是热带寄生虫，它们的载体和宿主。这些生物包括：恶性疟原虫、克氏锥虫、刚地弓形虫、曼氏血吸虫、按蚊、双脐线虫和人类。该提案旨在通过启动一项为期5年的有针对性的培训计划来满足CPqRR的需求，该计划涉及来自CPqRR 15个实验室中许多实验室的博士前和博士后学生。高级培训将通过巴西国内外的讲习班、课程、短期和长期培训进行。培训将涉及源自CPqRR需求的合作研究项目，重点关注血吸虫病的几个方面。这次培训的统一项目将是建立一个血吸虫基因组关系数据库，由CPqRR提供服务。该数据库将包含CPqRR生成的转录组数据和流行病学数据。分子进化培训将侧重于血吸虫病媒、双脐蚴和流行病学/生物统计数据，并将从现有资助项目中获得和分析这些数据。从这次培训和实施活动中获得的技术和知识将直接适用于其他寄生生物的研究。我们将积极寻找合格的培训候选人，他们有强烈的愿望返回，并将他们新获得的专业知识贡献给当地的卓越培训中心。

DESCRIPTION (provided by applicant): This proposal represents a collaborative training partnership between researchers at the University of Georgia, the George Washington University, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro and the Centro de Pesquisas Rene Rachou - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 15 laboratories and 3 funded NIH grants (A training grant in emerging and re-emerging diseases, an ICIDR grant on host genetic correlates in schistosomiasis and a grant on the genetic architecture of heart disease in rural Brazil". The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium falciparum, Trypanosoma cruzi, Toxoplasma gondii, Schistosoma mansoni, Anopheles, Biomphalaria and Humans. This proposal is designed to meet the needs of the CPqRR by initiating a 5-year targeted training program that involves pre-and post-doctoral students from many of the 15 laboratories at the CPqRR. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the creation of a Schistosoma genome relational database housed and served from the CPqRR. This database will house the transcriptome data and epidemiological data being generated by the CPqRR. Molecular evolution training will focus on the Schistosome vector, Biomphalaria and epidemiological/ biostatistical data will be derived and analyzed from existing funded projects. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a local training center of excellence.