MOLECULAR BASIS OF MALE INFERTILITY

本申请建议在贝勒医学院建立一个计划项目，以研究男性不育症，重点是调查精子产生异常的病因和辅助生殖技术的应用，以克服这些缺陷。该计划项目将以一个核心行政单位为核心，负责协调基础和临床科学家的日常活动。该计划项目的重点将是男性不育的分子生物学领域，特别强调定义正常精子发生所需的基因。辅助生殖技术已被用来克服许多男性因素的缺陷。人们认为，如果一个精子可以受精，那么它就是“健康的”。我们没有科学依据来支持这种信念，而且这些后代中的许多人可能携带有遗传缺陷。该提案的目的是：1。建立一个研究男性不育症的项目，在泌尿科、产科和妇科的基础和临床科学家之间建立密切的工作关系。细胞生物学和医学遗传学。将这些群体聚集在一个项目中，将比这些科学家单独工作更有效地关注男性不育。2.建立一个分析DNA和进行原位杂交的设施是本计划项目的一个重要和关键的组成部分。3.将男性不育的临床特征与mo水平的新发现相关联，以更好地了解疾病过程，从而开发更有效的治疗和诊断模式。这个多学科的科学家小组的专业知识，共同努力，预计将产生新的理解的基本病理生理学的男性不育症。

This application proposes the establishment of a Program Project at Baylor College of Medicine to study male infertility with a focus on investigation the etiology of abnormal sperm production and the application of assisted reproductive techniques to overcome these defects. The Program Project will have as its nucleus a core administrative unit that will coordinate the activities of the basic and clinical scientists on a day to day basis. The focus of this Program Project will be in the area of the molecular biology of male infertility with specific emphasis on defining the genes required for normal spermatogenesis. Assisted reproductive techniques have been used to overcome many male factor defects. It is assumed that if a sperm can fertilize, than it is "healthy". We have no scientific basis for this belief and many of these offspring could be carrying genetic defects. The aims for the proposal are: 1. To establish a program project for the study of male infertility creating a close working relationship between basic and clinical scientists from the Departments of Urology, Obstetrics and Gynecology., Cell Biology, and Medical Genetics. Bring these groups together in one project will create a more effective focus on male infertility than would occur with these scientists working individually. 2. To Create a facility to analyze DNA and perform in situ hybridization represents a significant a significant and critical component of this Program Project. 3. To correlate clinical features of male infertility with new discoveries at the mo level, to better understand the diseases processes and thereby to develop ad more effective treatment and diagnostic modalities. The expertise of this multi-disciplinary group of scientists working together is expected to yield new understanding of the basic pathophysiology of male infertility.