K-12: Male Reproductive Health Research (MRHR) Career Development Program at BCM

申请者描述(由申请者提供)：本申请旨在支持我们向贝勒医学院生殖医学中心和斯科特泌尿外科申请男性生殖健康研究培训助学金。该计划的研究重点是儿科泌尿/生殖发育、类固醇激素作用、干细胞和男性生殖生物学/男性不育等领域。培训人员包括7名博士/医学博士、博士和11名博士。兰姆博士将兼任MRHR培训项目的项目总监和研究总监。利普舒尔茨博士、冈萨雷斯博士、西塞克博士、赫拉博士、罗斯博士和詹森博士将确保学员在男性不育症和儿科泌尿科等泌尿外科子专业领域得到最佳培训。该计划的主要研究领域包括：泌尿生殖系统发育缺陷的遗传学和基因组学、细胞生物学、类固醇激素受体、男性生殖生物学/不育、遗传学、细胞周期控制、STE细胞、基因治疗和基因干扰。受训人员将是贝勒医学院的医学博士初级教员。我们的项目吸引了高素质的受训者，他们寻求在男性生殖健康研究方面进行密集和实质性的研究培训，重点是临床翻译。我们有一个明确的招聘计划，强调招聘妇女和少数群体。培训环境的优势包括备受尊敬、资金充足、经验丰富的教师，NIH资助的泌尿/细胞生物学和病理学系的全国排名，结构化的指导计划和必修课程，具有相关课程工作和细胞生物学和遗传学深度的细胞生物学研究生计划。我们的长期目标是培训这些年轻的研究人员，使他们能够成功地争取同行评审的资金，并最终在男性生殖健康研究方面增加基础和转化性研究的努力。 公共卫生相关性：这个MRHR应用程序将培训新的研究人员，使其成为男性健康问题的临床和基础研究人员。该计划将为研究人员提供基础和临床研究方面的培训，以改善男性的健康状况。

DESCRIPTION (provided by applicant): This application seeks support for our application for the Men's Reproductive Health Research Training Grant to the Center for Reproductive Medicine and the Scott Department of Urology at Baylor College of Medicine. The research emphasis of this program is in the areas of pediatric urology/genitourinary development, steroid hormone action, stem cells and male reproductive biology/male infertility. The training faculty includes 7 Ph.D/M.D., Ph.D. faculty and11 M.D.s. Dr. Lamb will serve as both the Program Director and the Research Director of the MRHR training program. Drs. Lipshultz, Gonzales, Cisek, Khera, Roth, and Janzen will ensure the trainees are optimally trained in the urologic subspecialty areas of male infertility and pediatric urology. The major research areas in the program include: genetics and genomics of genitourinary developmental defects, cell biology, steroid hormone receptors, male reproductive biology/infertility, genetics, cell cycle control, ste cells, gene therapy and gene disruption. The trainees will be M.D. junior faculty members at Baylor College of Medicine. Our program attracts highly qualified trainees who seek intensive and substantial research training in men's reproductive health research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high national ranking for NIH funding of Urology/Cell Biology and Pathology departments, a structured mentoring program and required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Our long-term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in men's reproductive health research. PUBLIC HEALTH RELEVANCE: This MRHR application will train new investigators to become clinical and basic researchers in men's health issues. This program will offer training in both basic and clinical research to investigators to improve men's health.