Multidisciplinary K12 Urologic Research (KURe) Career Development Program

多学科 K12 泌尿学研究 (KURe) 职业发展计划

• 批准号: 9325500
• 负责人: Dolores Jean Lamb
• 金额: --
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9325500
• 关键词: Alpha Cell; Area; Basic Science; Biology; Cell Cycle Regulation; Cellular biology; Childhood; Defect; Development; Doctor of Medicine; Doctor of Philosophy; Ensure; Environment; Faculty; Funding; Genetic; Genitourinary system; Genomics; Goals; Medicine; Mentors; Minority; Pathology; Peer Review; Physicians; Program Development; Recruitment Activity; Reproductive Health; Reproductive Medicine; Research; Research Personnel; Research Training; SECTM1 gene; Scientist; Stem cells; Structure; Teacher Professional Development; Training; Translational Research; United States National Institutes of Health; Urology; Woman; Work; career development; clinical translation; college; experience; gene therapy; lower urinary tract symptoms; male; male health; member; men; multidisciplinary; programs; reproductive tract; steroid hormone; steroid hormone receptor; strength training; urologic

DESCRIPTION (provided by applicant): This application seeks support for our competing renewal application for the Multidisciplinary K12 Urologic Research (KURe) Career Development Program to the Scott Department of Urology and the Center for Reproductive Medicine at Baylor College of Medicine. The research emphasis of this program is in the areas pediatric urology/genitourinary development, steroid hormone action, stem cells genetics and lower urinary tract symptoms (LUTS). The training faculty includes 7 Ph.D/M.D., Ph.D. faculty and11 M.D.s. Dr. Lamb will serve as both the Program Director and the Administrative Director of the KURe career development program. Dr. Boone will serve as co-Director. Drs. Lipshultz, Cunningham, Gonzales, Khera, Roth, Janzen will ensure the M.D. trainees are optimally trained in the urologic subspecialty areas of men's health and pediatric urology. The major research areas in the program include: genetics and genomics of genitourinary developmental defects, cell biology, steroid hormone receptors, male reproductive tract biology, genetics, cell cycle control, stem cells, gene therapy and LUTS. The trainees will be M.D. and Ph.D. junior faculty members at Baylor College of Medicine. Our program attracts highly qualified trainees who seek intensive and substantial research training in urology research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high ranking national ranking for NIH funding of a Urology/Cell Biology/Genetics/Pathology departments, a structured mentoring program with required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Most importantly, we have a strong track record of training successful physician scientists. Our long- term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in men's reproductive health research.

描述（由申请人提供）：本申请寻求支持我们的竞争性更新申请的多学科K12泌尿学研究（KURe）职业发展计划，泌尿外科和生殖医学中心在贝勒医学院的斯科特部门。该计划的研究重点是儿科泌尿学/泌尿生殖系统发育，类固醇激素作用，干细胞遗传学和下尿路症状（LUTS）。培训教师包括7名博士/医学博士，博士教师和11名医学博士Lamb博士将担任KURe职业发展计划的项目总监和行政总监。布恩博士将担任联合主任。Lipshultz，Cunningham，冈萨雷斯，Khera，Roth，Janzen医生将确保医学博士受训者最好在男性健康和小儿泌尿科的泌尿专科领域接受培训。该计划的主要研究领域包括：泌尿生殖系统发育缺陷的遗传学和基因组学，细胞生物学，类固醇激素受体，男性生殖道生物学，遗传学，细胞周期控制，干细胞，基因治疗和LUTS。实习生将是医学博士。和博士贝勒医学院的初级教员我们的计划吸引了高素质的学员谁寻求密集和实质性的研究培训泌尿外科研究，重点是临床翻译。我们有一个明确的招聘计划，强调招聘妇女和少数族裔。培训环境的优势包括备受尊敬，资金充足，经验丰富的教师，泌尿学/细胞生物学/遗传学/病理学部门的NIH资助的高排名国家排名，具有所需课程的结构化指导计划，具有相关课程工作的细胞生物学研究生课程以及细胞生物学和遗传学的深度。最重要的是，我们在培养成功的医生科学家方面有着良好的记录。我们的长期目标是培训这些年轻的研究人员成功地竞争同行评审的资金，并最终增加男性生殖健康研究的基础和转化研究工作。

项目成果

Imaging: CNS changes in interstitial cystitis/painful bladder syndrome.

影像学：间质性膀胱炎/膀胱疼痛综合征的中枢神经系统变化。

• DOI: 10.1038/nrurol.2015.142
• 发表时间: 2015
• 期刊: Nature reviews. Urology
• 作者: Khavari,Rose;Boone,Tim
• 通讯作者: Boone,Tim

New frontiers in molecular and imaging research on evaluation and diagnosis of bladder outlet obstruction in women.

女性膀胱出口梗阻评估和诊断的分子和影像学研究新前沿。

• DOI: 10.1007/s11884-017-0429-0
• 发表时间: 2017
• 期刊: Current bladder dysfunction reports
• 影响因子: 0.4
• 作者: Martinez,Laura;Khavari,Rose
• 通讯作者: Khavari,Rose

Treatment of Estrogen Levels in the Management of Hypogonadism: An Anonymous Survey of ISSM Members.

性腺功能减退症治疗中雌激素水平的治疗：ISSM 成员的匿名调查。

• DOI: 10.1016/j.urology.2020.01.032
• 发表时间: 2020
• 期刊: Urology
• 影响因子: 2.1
• 作者: Butaney,Mohit;Thirumavalavan,Nannan;Balasubramanian,Adithya;McBride,JAbram;Gondokusumo,Jabez;Pastuszak,AlexanderW;Lipshultz,LarryI
• 通讯作者: Lipshultz,LarryI

In vitro production of functional sperm in mice.

小鼠功能性精子的体外生产。

• DOI: 10.1038/aja.2011.98
• 发表时间: 2011
• 期刊: Asian journal of andrology
• 影响因子: 2.9
• 作者: Hwang,Kathleen;Lamb,DoloresJ
• 通讯作者: Lamb,DoloresJ

Racial differences in sexual dysfunction among postdeployed Iraq and Afghanistan veterans.

• DOI: 10.1177/1557988312471842
• 发表时间: 2013-09
• 期刊: American journal of men's health
• 作者: Hosain GM;Latini DM;Kauth MR;Goltz HH;Helmer DA
• 通讯作者: Helmer DA