Nanopore sensing of biomarkers in clinical samples using DNA origami nanostructures

最近的纳米孔传感研究集中在受体修饰的载体上，用于选择性纳米孔传感，这项新技术正在成为一种有前途的疾病诊断工具，因为它允许选择性地检测复杂生物体液中的目标分析物。本项目旨在设计和构建一种新型构型可变的DNA折纸载体，用于生物分子的单分子纳米孔传感。一般的想法是，当这种DNA折纸载体与目标生物标记物结合时，可以改变其结构。我们将探索在临床样本中检测生物标志物的检测策略。

Recent nanopore sensing studies have concentrated on receptor-modified carriers for selective nanopore sensing, and this new technique is emerging as a promising tool for disease diagnosis since it allows selective detection of target analytes in complex biological fluids. This project aims to design and construct a novel configuration changeable DNA origami carrier for single-molecule nanopore sensing of biomolecules. The general idea is that this DNA origami carrier can change its structure when bound with the target biomarkers. We will explore detection strategies for sensing biomarkers in clinical samples.