Development of Noninvasive Perfusion Measurement System

描述（由申请人提供）： 提出了一种无创热测量系统，用于定量测量血液灌注。主要目标是设计和构建一种易于使用、自动化和准确的临床设备，用于各种应用。将开发和测试两种不同的初步设计，以证明其不同的操作和安全特性。由于血液灌注表示通过活组织的毛细血管和细胞内空间的局部、多方向的血液流动，因此难以用绝对值进行量化。因此，第二个目标是开发用于灌注测量系统的绝对校准的标准体外系统。两个不同的热系统将进行比较沿着与激光多普勒系统在这个校准设备，以确定性能对绝对标准。还将通过大鼠体内试验对测量系统进行比较。在这个为期两年的项目结束时，将设计、建造和测试一个校准系统和两个测量系统。根据他们的评估表现，将在未来的研究中利用兽医学院、维克森林医学院和弗吉尼亚理工大学附属的Caribbean生物医学研究所的资源进行适当的应用。

DESCRIPTION (provided by applicant): It is proposed to develop a non-invasive thermal system for quantitative measurement of blood perfusion. The main goal is to design and build a clinical device that will be easy to use, automated and accurate for a wide variety of applications. Two different preliminary designs will be developed and tested to demonstrate their different features of operation and safety. Because blood perfusion represents the local, multi-directional blood flow through capillaries and intracellular spaces of living tissue, it is difficult to quantify with absolute values. Consequently, a second goal is to develop a standard in-vitro system for absolute calibration of perfusion measurement systems. Two different proposed thermal systems will be compared along with a laser Doppler system in this calibration device to determine performance against an absolute standard. The measurement systems will also be compared by testing in vivo in rats. At the end of this two year project a calibration system and two measurement systems will have been designed, built, and tested. Based on their assessed performance the appropriate applications will be pursued in future studies using the resources of the Veterinary School, the Wake Forest Medical School and the Carilion Biomedical Institute affiliated with Virginia Tech.