Noninvasive blood perfusion measurements of an isolated rat liver and an anesthetized rat kidney.
Noninvasive blood perfusion measurements of an isolated rat liver and an anesthetized rat kidney.
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DOI：
10.1115/1.2978989
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发表时间：
2008-12
影响因子：
1.7
通讯作者：
Scott, Elaine P.
中科院分区：
文献类型：
--
作者：
Mudaliar, Ashvinikumar V.;Ellis, Brent E.;Ricketts, Patricia L.;Lanz, Otto I.;Lee, Charles Y.;Diller, Thomas E.;Scott, Elaine P.
在动物模型中测试了一种简单、经济高效且无创的血液灌注系统。该系统使用小型传感器来测量对组织表面施加的热事件（对流冷却）的传热响应。将热通量数据与组织的数学模型进行比较，以估计组织与探头之间的血液灌注和热接触阻力。使用离体大鼠肝脏和暴露的大鼠肾脏测试来评估灌注系统的重复性和敏感性。离体肝脏测试中的灌注通过控制灌注液进入肝脏的流量来改变，暴露的肾脏测试中的灌注通过暂时阻断流经肾动脉和静脉的血流来改变。对流灌注探针估计的灌注与进入肝脏模型的灌注液的计量流量非常一致。肝脏测试表明探针可用于检测灌注的微小变化（0.005 ml/ml/s）。该探针定性地跟踪了由于肾动脉和静脉闭塞而导致的肾脏模型灌注的变化。
A simple, cost effective, and noninvasive blood perfusion system is tested in animal models. The system uses a small sensor to measure the heat transfer response to a thermal event (convective cooling) imposed on the tissue surface. Heat flux data are compared with a mathematical model of the tissue to estimate both blood perfusion and thermal contact resistance between the tissue and the probe. The perfusion system was evaluated for repeatability and sensitivity using isolated rat liver and exposed rat kidney tests. Perfusion in the isolated liver tests was varied by controlling the flow of the perfusate into the liver, and the perfusion in the exposed kidney tests was varied by temporarily occluding blood flow through the renal artery and vein. The perfusion estimated by the convective perfusion probe was in good agreement with that of the metered flow of the perfusate into the liver model. The liver tests indicated that the probe can be used to detect small changes in perfusion (0.005 ml/ml/s). The probe qualitatively tracked the changes in the perfusion in the kidney model due to occlusion of the renal artery and vein.
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影响因子：
3.1
作者：
Boellaard, R;Knaapen, P;Lammertsma, AA
通讯作者：
Lammertsma, AA
影响因子：
2.2
作者：
Li, HJ;Zhang, XX;Yi, YF
通讯作者：
Yi, YF
DOI：
10.1097/01.bcr.0000076091.79370.56
发表时间：
2003-07-01
期刊：
JOURNAL OF BURN CARE & REHABILITATION
影响因子：
--
作者：
Mileski, WJ;Atiles, L;Hunt, JL
通讯作者：
Hunt, JL
影响因子：
6.7
作者：
Montet, X;Ivancevic, MK;Vallée, JP
通讯作者：
Vallée, JP
影响因子：
4.1
作者：
Vajkoczy, P;Roth, H;Schmiedek, P
通讯作者：
Schmiedek, P