SPORE in Prostate Cancer

描述(由申请人提供) 这份孢子申请是应国家足协的 癌症研究所将利用前列腺癌的优势 罗伯特·H·卢里综合癌症研究所的研究和治疗 中心。孢子将提供基础设施，将基本的 科学家和临床医生迅速测试预防的新方法， 人类前列腺癌的早期发现、诊断和治疗。这个 孢子的具体主题是： 1.前列腺癌的细胞和分子生物学 2.前列腺癌发生的预防和危险因素 3.前列腺癌的创新治疗和康复 4.前列腺癌患者的生活质量和预后研究 孢子应用包括六个主要研究项目，三个 职业发展项目、五个试点项目和四个核心设施，以 支持研究。主要研究项目有：1)Clusterin和 抗凋亡(Lee)，2)钙网织蛋白的抑制作用 前列腺癌(Wang)，3)前列腺癌依赖的血管抑素生成 4.5(Soff)，4)勃起功能障碍的分子机制(McVary)，5) 番茄红素对前列腺组织的影响(GANN)，6)生活质量 前列腺癌银行业务(CELA)。核心设施包括： 管理、组织资源、临床和生物统计学核心。这个 被选为孢子计划一部分的调查人员来自各种不同的 学科范围从临床课程到化学工程、病理学 和化学。为了保持调查人员之间有意义的沟通，我们 将每月召开孢子调查员会议，每年举行一次务虚会，并 执行委员会的月度会议。基于基础设施 描述，我们庞大的患者群体和我们的生产力记录， 我们认为罗伯特·H·卢里综合癌症中心非常适合 关于孢子项目的。

DESCRIPTION(provided by applicant) This SPORE application submitted in response to the RFA from the National Cancer Institute, will take advantage of the strengths in prostate cancer research and treatment that exist at the Robert H. Lurie Comprehensive Cancer Center. The SPORE will provide the infrastructure to bring together basic scientists and clinicians to rapidly test new approaches in the prevention, early detection, diagnosis and treatment of human prostate cancer. The specific themes of the SPORE are: 1. Cell and molecular biology of prostate cancer 2. Prevention and risk factors in prostate cancer development 3. Prostate cancer innovative therapeutics and rehabilitation 4. Quality of life and outcomes research in prostate cancer The SPORE application consists of six principal research projects, three career development projects, five pilot projects and four Core facilities to support the research. The principal research projects are: 1) Clusterin and resistance to apoptosis (Lee), 2) Suppressive role of calreticulin in prostate cancer (Wang), 3) Prostate cancer dependent generation of angiostatin 4.5 (Soff), 4) Molecular mechanisms of erectile dysfunction (McVary), 5) Effects of lycopene on prostatic tissue (Gann), 6) Quality of life item banking in prostate cancer (Cella). The Core facilities include: Administration, Tissue Resource, Clinical and Biostatistical Cores. The investigators selected to be part of the SPORE Program come from a variety of disciplines ranging from Clinical Programs to Chemical Engineering, Pathology and Chemistry. To maintain meaningful communication between investigators, we will have monthly meetings of SPORE investigators, an annual retreat and monthly meetings of the Executive Committee. Based on the infrastructure described, our large patient population and our track record of productivity, we believe that the Robert H. Lurie Comprehensive Cancer Center is well suited for the SPORE program.