Small molecule screening program

人类基因组计划使得使用高通量技术在遗传和分子水平上研究细胞和组织的生物学变得越来越可能。美国国立卫生研究院化学基因组学中心（NCGC）是作为美国国立卫生研究院路线图分子文库倡议的一部分创建的，旨在帮助建立化学基因组学计划，定义为使用小有机化合物来研究基因组编码的基因产物和途径。通过在学术领域提供鉴定靶标、途径和细胞表型的生物活性化合物的能力，该项目将为广泛的研究人员带来小分子筛选、化学和信息学的力量和多样性，这些研究人员试图确定基因组编码的数万个人类基因的功能。今天，只有不到500种人类基因产物具有与它们相互作用的化合物。NCGC与其他由校外分子文库筛选中心网络RFA资助的中心一起，将探索绝大多数尚未确定小分子化学探针的人类基因组。这一举措有望显著提高对基因及其蛋白质产物功能机制的理解，并加速基于基因组知识的人类疾病治疗方法的开发。

The Human Genome Project has made it increasingly possible to study the biology of cells and tissues at the genetic and molecular level using high-throughput technologies. The NIH Chemical Genomics Center (NCGC) was created as part of the NIH Roadmap Molecular Libraries Initiative, to help establish a program in chemical genomics, defined as the use of small organic compounds to study gene products and pathways encoded by the genome. By providing capacities in the academic sector to identify bioactive compounds for targets, pathways, and cellular phenotypes, this program will bring the power and diversity of small-molecule screening, chemistry, and informatics to broad array of researchers attempting to determine the function of the tens of thousands of human genes encoded by the genome. Today, there are less than 500 human gene products have chemical compounds that interact with them. The NCGC, together with other centers to be funded via the extramural Molecular Libraries Screening Center Network RFA, will explore the vast majority of the human genome for which no small-molecule chemical probes have been identified. This initiative promises to significantly improve the understanding of mechanisms by which genes and their protein products function and accelerate the development of therapies for human diseases based on knowledge of the genome.