Development Of Cognitive Activation Tasks For Functional

我们已经开发了各种任务来激活功能神经成像研究中的感兴趣区域。 1.为了检验情景记忆功能中回忆和熟悉之间的区别，我们开发了一项使用视觉场景的任务，该任务可靠地在控制中诱发基于熟悉的错误。 2.我们评估了儿茶酚-O-甲基转移酶(COMT)基因在功能性磁共振成像(FMRI)事件相关研究中的作用，该研究评估了认知控制在不同条件下对所谓侧翼任务的干扰的影响。 3.采用正电子发射断层扫描脑血流图(Positron Emit Tomography Car Blow，PET CBF)方法，设计了一套精心匹配的词汇流利性任务，考察了精神分裂症患者的语义加工、思维障碍和神经生理学之间的关系。我们发现下前额叶皮质(PFC)中的一个区域在语义流畅性方面更活跃，并与精神分裂症的一种经典症状--思维障碍--相关。 4.我们正在使用一种新颖的更新任务，该任务允许通过要求在每个试验中对单个或多个帧进行操作来参数地改变“更新量”。这项技术将使我们能够检查在背外侧前额叶皮质中是否存在负荷和延迟之间的相互作用，以及这种相互作用如何以及是否可能涉及前额叶皮质内的不同分区。

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. To examine the distinction between recall and familiarity in episodic memory function we have developed a task using visual scenes that reliably induces familiarity based errors in controls. 2. We assessed the role of Catecol-O-methyltransferase(COMT) genotype in a functional Magnetic Resonance Imaging (fMRI) event related study which gauged the effects of cognitive control on various conditions involving interference in the so called flanker task. 3. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF (Positron Emission Tomography Cerebral Blood Flow) methods. We found an area in inferior prefrontal cortex (PFC) that was more activated in semantic fluency and correlated with a classic symptom of schizophrenia -- thought disorder. 4. We are using a novel updating task which allows the amount of "updating" to be varied parametrically by demanding operations on single or multiple frames within each trial. This technique will allow us to examine whether there is an interaction between load and delay in the dorsolateral prefrontal cortex and how and whether such interactions may engage different subdivisions within the prefrontal cortex.