NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases

描述（由申请人提供）：拟建的多学科临床研究中心（MCRC）是北卡罗来纳大学教堂山分校瑟斯顿关节炎研究中心多用途关节炎和肌肉骨骼疾病中心流行病学教育/健康服务研究部分的自然产物。中心拥有一支经验丰富的研究人员和管理人员队伍，与医学院、公共卫生学院、牙科学院、药学学院、护理学院以及医学系、儿科、骨科、家庭医学、社会医学、放射学、流行病学、健康行为与健康教育、卫生政策与管理、生物统计学等部门有直接联系。MCRC的目标是1)在各种肌肉骨骼疾病中进行严格的跨学科临床研究；2)指导方法论核心，以支持获资助项目和其他未来项目在方法论、分析和统计方面的需要；3)促进关节炎和肌肉骨骼疾病新研究思路的发展和新研究项目的资助。为了实现这些目标，拟议的MCRC将由方法论核心、三个临床项目和一个行政核心组成。方法学核心将构成中心的基础，并将发挥以下职能：1)方法学和生物统计学咨询和审查；2)测量开发；3)数据支持服务，包括数据收集、数据管理和分析；4)数据和安全监控；5)教学。拟建的三个项目是：1)金属在多民族农村人群骨关节炎中的作用（首席研究员：Joanne Jordan博士）；2)关节炎结局的个人和社区社会决定因素（首席研究员：Leigh Callahan博士）；3)血管炎患者及其伴侣的社会支持、感知控制和心理适应（首席研究员：Robert DeVellis博士）。这些项目包括针对不同患者群体的流行病学和生物行为学方法：北卡罗来纳州特定农村社区的骨关节炎；横跨北卡罗来纳州的社区家庭实践中的关节炎；以及东南地区的小血管炎。每个项目都是创新的，解决了在关节炎和风湿性疾病的背景下很少或从未研究过的问题。每个项目研究领域的一个共同主题是个人领域之外的影响和问题。在第一个项目中，环境暴露是个体之外的力量。在第二个项目中，重点是一个人生活的社区的社会经济地位对关节炎结果的影响。最后，个人与配偶的互动是第三个项目探究的重点。行政核心将为该中心提供财务和科学监督和指导，并将由一名主任、一名副主任、一个执行委员会和支助人员组成。

DESCRIPTION (provided by applicant): The proposed Multidisciplinary Clinical Research Center (MCRC) is a natural outgrowth of the Epidemiology Education/Health Services Research Component of the Multipurpose Arthritis and Musculoskeletal Diseases Center of the Thurston Arthritis Research Center at the University of North Carolina at Chapel Hill. The center has a large cadre of experienced researchers and administrators with direct linkages to the Schools of Medicine, Public Health, Dentistry, Pharmacy, and Nursing and to the Departments of Medicine, Pediatrics, Orthopaedics, Family Medicine, Social Medicine, Radiology, Epidemiology, Health Behavior and Health Education, Health Policy and Administration, and Biostatistics. The objectives of the MCRC are 1) to conduct rigorous interdisciplinary clinical research in a variety of musculoskeletal conditions; 2) to direct a Methodology Core to support the methodological, analytical, and statistical needs of the funded projects and other future projects; and 3) to foster the development of new research ideas and the funding of new research projects in arthritis and musculoskeletal diseases. In order to achieve these goals, the proposed MCRC will consist of a Methodology Core, three clinical projects, and an Administrative Core. The Methodology Core will form the foundation of the Center and will serve the following functions: 1) methodological and biostatistical consultation and review; 2) measurement development; 3) data support services including data collection, data management, and analysis; 4) data and safety monitoring; and 5) teaching. The three proposed projects are 1) The role of metals in osteoarthritis in a multi-ethnic, rural population (Principal Investigator: Dr. Joanne Jordan); 2) Individual and Community Social Determinants of Arthritis Outcomes (Principal Investigator: Dr. Leigh Callahan); and 3) Social support, perceived control, and psychological adjustment in vasculitis patients and their partners (Principal Investigator: Dr. Robert DeVellis). The projects include epidemiologic and biobehavioral approaches to distinct patient populations: osteoarthritis in a specific rural community in North Carolina; arthritis in community family practices spanning the state of North Carolina; and small vessel vasculitis from practices across the Southeast. Each project is innovative and addresses issues which have rarely or never been examined in the context of arthritis and rheumatic diseases. A common theme to the area of inquiry of each project is that of influences and issues outside the realm of the individual. In the first project, environmental exposures are the forces outside the individual. In the second project, the focus is the impact of the socioeconomic status of the community in which one lives upon arthritis outcomes. Finally, the interaction of the individual and his/her spouse is the focus of inquiry of the third project. An Administrative Core will provide financial and scientific oversight and direction to the Center and will be composed of a Director, an Associate Director, an Executive Committee, and support staff.