Non-adherence to medication and drug toxicity: tuberculosis treatment in the era of the World Health Organization's End Tuberculosis Strategy

该项目的目的是调查不依从性和结核病治疗副作用之间的关系，以及这对重新引入药物和治疗结果的影响。希望通过完成以下三个目标来实现这一目标。首先，将确定使用流行病学方法治疗的副作用造成的负担和不依从的模式。其次，将描述患者在结核病治疗过程中经历的副作用的类型和严重程度，以及它们与不同的不依从模式的关系。最后，在因肝毒性住院的个体中，将使用常规工具和新型高灵敏度机制生物标志物表征药物重新引入后毒性复发的频率和临床特征。此外，确定是否可以使用这些生物标志物与传统的临床测试更早地检测到严重的复发。

The aim of this project is to investigate the relationship between non-adherence to, and side effects from, TB treatment and the implications of this for the reintroduction of medication and treatment outcomes. It is hoped that this aim will be achieved by completing the following three objectives. Firstly, the burden and patterns of non-adherence due to side effects from treatment using epidemiological approaches will be determined. Secondly, the types and severity of side effects experienced by patients during their TB treatment course and their relationship with different non-adherence patterns will be characterised. Lastly, among individuals hospitalised with liver toxicity, the frequency and clinical features of toxicity recurrence following medicine re-introduction will be characterised using conventional tools and novel high sensitivity mechanistic biomarkers. Additionally, determine if a severe recurrence can be detected earlier using these biomarkers versus traditional clinical tests.