Video Information Provider for HIV-Associated Non-AIDS (VIP-HANA) Symptoms

 描述(由申请人提供)：艾滋病毒相关非艾滋病视频信息提供者(VIP-HANA)症状、与艾滋病有关的恶性肿瘤和死亡是1990年代中期以前艾滋病毒流行的显著特征。今天，美国20岁的艾滋病毒阳性非注射吸毒者预计可以活到65岁。因此，艾滋病毒/艾滋病患者(PLWHA)面临着来自艾滋病毒相关非艾滋病(HANA)疾病的新挑战，如心血管疾病、骨质疏松症、慢性阻塞性肺病和糖尿病。由于治疗不能完全恢复免疫健康，而且多种发病率很高，PLWHA，特别是那些患有HANA疾病的人，往往会因疾病及其治疗而再次出现症状，因此对症状的长期管理对于改善健康结果至关重要。个人自我管理艾滋病毒疾病症状的能力已被证明可以降低症状严重程度，提高生活质量，减少残疾，增加服药依从性，并促进健康。拟议的研究扩展了我们的创新试点工作，开发和测试了一个基于网络的症状报告和自我管理系统，即PLWHA的视频信息提供商(VIP)。这项拟议研究的工作目标是开发和测试干预措施-VIP-HANA系统，这是一个网络应用程序，提供根据症状报告、HANA状况(S)和性别定制的自我护理策略。为了满足日益增长的有HANA条件的PLWHA人群的需求，我们的研究目的是：(1)确定有HANA条件的PLWHA最常见的症状和自我护理策略，以便将VIP-HANA系统修改为VIP-HANA系统；(1)评估VIP-HANA系统是否违反了可用性原则；(2)比较VIP-HANA和对照组在100例有HANA条件的PLWHA患者中改善症状频率和强度的疗效以及6个月的二次健康结果；以及(3)通过理论指导的焦点小组会议，了解PLWHA对VIP-HANA使用的易感、促进和强化因素的看法。我们的研究活动集中于确定具有HANA条件的PLWHA的症状体验和自我护理策略，并增强现有的艾滋病毒症状自我管理的网络应用程序。拟议的项目侧重于VIP-HANA的开发和评估，这是一种旨在改善症状状态、提高生活质量、增加功能能力和减少PLWHA脆弱性的干预措施。拟议的研究符合FOA：PA 13-210“旨在识别和管理与艾滋病毒相关的非艾滋病(HANA)条件有关的症状的发展、适应或测试干预措施，特别是功能能力和脆弱程度，并加强HANA条件下艾滋病毒感染者的自我护理。”这项研究的结果将增加对HANA症状的了解，用于管理这些症状的自我护理策略，以及VIP-HANA系统的可用性和有效性。

 DESCRIPTION (provided by applicant): Video Information Provider for HIV-Associated Non-AIDS (VIP-HANA) Symptoms AIDS-related malignancies and death were hallmark features of the HIV epidemic until the mid-1990s. Today, a 20-year-old HIV-positive non-injection drug user in the US can expect to live to age 65. As a result, people living with HIV/AIDS (PLWHA) face new challenges from HIV-Associated Non-AIDS (HANA) conditions such as cardiovascular disease, osteoporosis, COPD, and diabetes. Since treatment does not fully restore immune health and multi-morbidity is high, PLWHA, especially those with HANA conditions, often experience re- occurring symptoms from both the disease and its treatment, making long-term management of symptoms critical for improved health outcomes. An individual's ability to self-manage the symptoms of his or her HIV illness has been shown to decrease symptom severity, improve quality of life, reduce disability, increase medication adherence, and promote health. The proposed research expands upon our innovative pilot work that developed and tested a web-based symptom reporting and self-management system, Video Information Provider (VIP) for PLWHA. The goal of the work in this proposed study is to develop and test an intervention, the VIP-HANA system, a web application that delivers self-care strategies tailored to symptom reporting, HANA condition(s) and gender. To address the needs of the growing population of PLWHA with HANA conditions, the aims of our study are to: (1a) Identify the most prevalent symptoms and self-care strategies of PLWHA with HANA conditions in order to modify the VIP system into the VIP-HANA system; (1b) Evaluate the VIP-HANA system for violations of usability principles; (2) Compare the efficacy of VIP-HANA to a control arm for ameliorating symptom frequency and intensity and secondary health outcomes in 100 PLWHA with HANA conditions over 6 months; and (3) Understand PLWHA's perceptions of the predisposing, enabling, and reinforcing factors for VIP-HANA use with theoretically-guided focus group sessions. Our study activities are focused on identifying the symptom experience and self-care strategies for PLWHA with HANA conditions and enhancing an existing web application for HIV symptom self-management. The proposed project focuses on the development and evaluation of VIP-HANA, an intervention aimed at improving symptom status, enhancing quality of life, increasing functional capacity, and reducing frailty in PLWHA. The proposed study is consistent with FOA: PA 13-210 "development, adaptation, or testing interventions aimed at identifying and managing symptoms related to HIV-Associated Non-AIDS (HANA) conditions, specifically functional capacity and frailty and increasing self-care of HIV-infected persons with HANA conditions." Findings from this study will increase knowledge of HANA symptoms, self-care strategies used to manage these symptoms, and the usability and efficacy of the VIP-HANA system.